Synthesis, structure, and properties of a polymeric copper(II) complex with anion of maleic acid

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dc.contributor.authorGuliyeva, Esmira Arif Aga
dc.contributor.authorMejidov, Ajdar Akper
dc.contributor.authorIsmayilov, Rayyat Huseyn
dc.contributor.authorRustam, Malahat Bagiyeva
dc.contributor.authorYalcin, Bahattin
dc.contributor.authorOzturkkan, Fureya Elif
dc.contributor.authorSahin, Onur
dc.date.accessioned2026-04-25T14:19:49Z
dc.date.available2026-04-25T14:19:49Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractA new polymeric copper(II)-maleato complex, used as a dicarboxylate ligand, was synthesized {Na2[Cu(C4H2O4)2]2H2O}n (1). The resulting complex was characterized by elemental analysis, infrared and UV-visible spectroscopy, and X-ray crystallography. Spectroscopic data indicate that the maleato ion coordinates in a chelating bidentate mode, creating a distorted square planar coordination environment around Cu(II). X-ray crystallography confirmed the formulation (1) and revealed that the central Cu(II) ion is in a distorted square planar. The maleato ion acts as a bidentate chelator, coordinating through two carboxylate oxygens to form a stable four-membered ring. This study extends our understanding of the coordination behavior of pi-conjugated dicarboxylic acids with transition-metal ions. Molecular docking studies demonstrated that the polymeric copper(II)-maleic acid complex exhibited strong binding affinity toward B-DNA (1BNA), with a binding energy of - 10.2 kcal/mol and multiple stable hydrogen bond interactions. The molecular docking results demonstrated that the polymeric copper(II) complex with maleic acid forms conventional hydrogen bonds with B-DNA. Specifically, interactions were observed with guanine and cytosine bases: the O2 atom of cytosine (DC21), the O4 ' atom of guanine (DG24), and the hydrogen atoms of guanine residues DG2, DG4, and DG22. The hydrogen bond distances (2.10-2.89 & Aring;) confirm the stability of these interactions. Moreover, several of these interactions are located within or near the minor groove of DNA, indicating a groove-binding mode. In addition, the complex exhibits an intramolecular hydrogen bond that stabilizes its conformation during binding.
dc.description.sponsorshipMinistry of Science and Education at the Institute of Catalysis and Inorganic Chemistry [0115]
dc.description.sponsorshipThis work was carried out under the research program of the Ministry of Science and Education at the Institute of Catalysis and Inorganic Chemistry named after Academician M. Nagiev (State Registration No. 0115). The authors acknowledge to Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8 QUEST diffractometer. CCDC-2465966 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via deposit@ccdc.cam.ac.uk or http://www.ccdc.cam.ac.uk/data_request/cif).
dc.identifier.doi10.1007/s11243-025-00705-y
dc.identifier.issn0340-4285
dc.identifier.issn1572-901X
dc.identifier.issue1
dc.identifier.orcid0000-0003-4648-0188
dc.identifier.scopus2-s2.0-105023959755
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11243-025-00705-y
dc.identifier.urihttps://hdl.handle.net/11486/8209
dc.identifier.volume51
dc.identifier.wosWOS:001630700200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofTransition Metal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subject#BAŞV!
dc.titleSynthesis, structure, and properties of a polymeric copper(II) complex with anion of maleic acid
dc.typeArticle

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