Novel Schiff base-Pt(ii) complexes: inhibition of Aβ aggregation via histidine interaction

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dc.contributor.authorIrisli, Sevil
dc.contributor.authorDogan, Umut
dc.contributor.authorGunnaz, Salih
dc.contributor.authorYurt, Fatma
dc.contributor.authorSahin, Onur
dc.date.accessioned2026-04-25T14:20:05Z
dc.date.available2026-04-25T14:20:05Z
dc.date.issued2026
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, three Schiff base ligands (L1-L3) and their novel platinum(ii) complexes (I-III) were synthesized and characterized using FT-IR, NMR, and elemental analysis. The crystal structure of complex I was determined by X-ray crystallography, while the lipophilicity of the complexes was evaluated by UV-Vis spectroscopy. The ability of the compounds to inhibit A beta aggregation was assessed using the SH-SY5Y human neuroblastoma cell line. Due to its high cytotoxicity, comparable to that of cisplatin, complex II was excluded from further biological investigations. The kinetics of A beta aggregation inhibition were examined fluorometrically using Thioflavin-T, and the binding interactions of the complexes with the A beta 1-42 sequence were elucidated through studies of their interactions with l-histidine using 1H-NMR and LC/QTOF/MS analyses. The results demonstrate that complexes I and III significantly suppress A beta fibril formation, with IC50 values of 50 mu M and 25 mu M, respectively. The enhanced biological activity is attributed to the strong electron-donating properties of the ligand substituents. Overall, these findings reveal that the synthesized complexes effectively inhibit A beta amyloid aggregation and promote cell viability.
dc.identifier.doi10.1039/d5nj04180e
dc.identifier.endpage1138
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue2
dc.identifier.orcid0000-0002-7422-6593
dc.identifier.orcid0000-0002-9394-6908
dc.identifier.scopus2-s2.0-105025230160
dc.identifier.scopusqualityQ2
dc.identifier.startpage1125
dc.identifier.urihttps://doi.org/10.1039/d5nj04180e
dc.identifier.urihttps://hdl.handle.net/11486/8348
dc.identifier.volume50
dc.identifier.wosWOS:001643910100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofNew Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subject#BAŞV!
dc.titleNovel Schiff base-Pt(ii) complexes: inhibition of Aβ aggregation via histidine interaction
dc.typeArticle

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