Synthesis, structural characterization and evaluation of anticancer activity of polymeric silver(I) complexes based on niflumic acid/naproxen and picoline derivatives

dc.contributor.authorCaglar, Sema
dc.contributor.authorAltay, Ahmet
dc.contributor.authorHarurluoglu, Betul
dc.contributor.authorYeniceri, Esma K. K.
dc.contributor.authorCaglar, Bulent
dc.contributor.authorSahin, Onur
dc.date.accessioned2025-03-23T19:35:23Z
dc.date.available2025-03-23T19:35:23Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractTwo polymeric mixed-ligand silver(I) complexes, [Ag(mu-nif)(4-pic)](n) (1) and [Ag-4(mu-nap)(4)(2-pic)(2)](n) (2), where Hnif: niflumic acid, Hnap: naproxen, 4-pic: 4-picoline and 2-pic: 2-picoline, were synthesized and characterized by single-crystal X-ray diffraction, FT-IR and H-1 NMR spectroscopies, elemental and thermal analysis techniques. In 1, nif ligand behaves as a mu(3)-N,O,O' bridge connecting three silver(I) ions and each silver(I) ion exhibits a seesaw geometry. In 2, nap ligands act as a mu-carboxylato-(O,O') bridge between two silver(I) ions and mu(3)-carboxylato-(O,O,O') bridge linking three silver(I) ions. Each silver(I) ion occurs in trigonal geometry. To uncover the anticancer properties of the complexes, first, their cytotoxic abilities were tested against three cancer cell lines, HT-29 (human colorectal adenocarcinoma), A-549 (human lung carcinoma), and MDA-MB-453 (human breast adenocarcinoma), and normal 3T3-L1 (mouse fibroblast) cell line by XTT tests. Afterwards, the anticancer mechanism of the complexes was tried to be elucidated through the flow cytometry analyzes. XTT assay results showed that the complexes exhibited the highest cytotoxic activity and selectivity on HT-29 cells among all the cell lines. Flow cytometry analyses revealed that both complexes induced the apoptosis through the mitochondrial membrane depolarization and activation of the caspase cascade in HT-29 cells.
dc.description.sponsorshipErzincan Binali Yildirim University Scientific Research Projects Coordination Commission (EU-BAP) [FBA-2020-683]
dc.description.sponsorshipThis work was financially supported by grants from Erzincan Binali Yildirim University Scientific Research Projects Coordination Commission (EU-BAP) (Project No: FBA-2020-683).
dc.identifier.doi10.1080/00958972.2022.2045586
dc.identifier.endpage196
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue1-2
dc.identifier.scopus2-s2.0-85125915035
dc.identifier.scopusqualityQ3
dc.identifier.startpage178
dc.identifier.urihttps://doi.org/10.1080/00958972.2022.2045586
dc.identifier.urihttps://hdl.handle.net/11486/5859
dc.identifier.volume75
dc.identifier.wosWOS:000769575800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectSilver(I)
dc.subjectNSAIDs
dc.subjectcell culture
dc.subjectcytotoxicity
dc.subjectapoptosis
dc.titleSynthesis, structural characterization and evaluation of anticancer activity of polymeric silver(I) complexes based on niflumic acid/naproxen and picoline derivatives
dc.typeArticle

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