In vitro effects of iron chelation of curcumin Fe (III) complex

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dc.authoridAlizade, Ares/0000-0003-0334-8152
dc.contributor.authorOzbolat, Guluzar
dc.contributor.authorYegani, Arash Alizadeh
dc.date.accessioned2025-03-23T19:27:38Z
dc.date.available2025-03-23T19:27:38Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractPurpose: The aim of this study was to investigate the cytotoxicity effect, iron chelator and antioxidant activities of iron (III) ions with curcumin ligand that may be used in the treatment of iron overload. Materials and Methods: The cytotoxic activities of the ligand and the complex were evaluated by the MTT assay. The SOD activity of the complex of curcumin was determined by using its ability to inhibit the reduction of NBT. The catalytic activity studies of Fe(III) complex in DMSO towards the disproportionation of hydrogen peroxide were also performed. Results: The IC50 values are found in 6.8 mu M catalase activity was measured. Where at a concentration of 2.0 mM, the activity was equivalent to 183.30 U/L. The complex shows a catalase activity. The complex showed minimal toxicity. IC50 values found 5.3 mg/ml. The observed cytotoxicity could be pursued to obtain a potential drug. The iron chelator effects were determined by Ferrozine reagent. Curcumin, the most active extract interfered with the formation of ferrous and ferrozine complex. It demonstrated strong chelating activities. The result showed that the complexes possess considerable SOD activity. This finding indicates that the iron complex is capable of removing free radicals. Conclusion: The study results revealed that the iron(III) complex of curcumin with an appropriate potential drug may act as a protector against oxidative stress. Therefore, all results suggest that curcumin may represent a new approach in the treatment of iron overload.
dc.identifier.doi10.17826/cumj.484672
dc.identifier.endpage952
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue3
dc.identifier.scopusqualityN/A
dc.identifier.startpage947
dc.identifier.trdizinid382344
dc.identifier.urihttps://doi.org/10.17826/cumj.484672
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/382344
dc.identifier.urihttps://hdl.handle.net/11486/4957
dc.identifier.volume44
dc.identifier.wosWOS:000500930000032
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectCurcumin
dc.subjectiron overload
dc.subjectiron(III)
dc.titleIn vitro effects of iron chelation of curcumin Fe (III) complex
dc.typeArticle

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