The association between circulating endothelial progenitor cells and coronary collateral formation

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dc.authoridCanpolat, Ugur/0000-0002-4250-1706
dc.authoridOto, Sibel/0000-0003-0171-4200
dc.authoridGurses, Kadri Murat/0000-0003-3904-0985
dc.contributor.authorTokgozoglu, Lale
dc.contributor.authorYorgun, Hikmet
dc.contributor.authorGurses, Kadri Murat
dc.contributor.authorCanpolat, Ugur
dc.contributor.authorAtes, Ahmet Hakan
dc.contributor.authorTulumen, Erol
dc.contributor.authorKaya, Ergun Baris
dc.date.accessioned2025-03-23T19:41:57Z
dc.date.available2025-03-23T19:41:57Z
dc.date.issued2011
dc.departmentSinop Üniversitesi
dc.description.abstractAim: We investigated the relationship between coronary collateral formation and circulating endothelial progenitor cells (EPC) in patients undergoing coronary angiography. Methods and results: Circulating CD133(+)/34(+) and CD34(+)/KDR+ EPCs were determined in 68 patients (normal coronary vessels in 24 patients and coronary artery disease (CAD) in 44 patients) (age: 58.7 + 10.1, 64.7% male). Circulating EPCs were higher among patients with normal coronary vessels compared to patients with CAD for CD133(+)/34(+) (p < 0.05) and CD34(+)/KDR+ cells (p < 0.05). The number of EPCs were significantly greater in patients with good coronary collateral formation (p < 0.05). EPC count was independent predictor for coronary collateral formation after adjustment for other cardiovascular risk factors and extent of CAD (p = 0.037). Conclusion: In patients with severe coronary stenosis, those with increased circulating EPCs had better collateral formation compared to those with lower EPC counts. Our findings implicate that in addition to presence of critical stenosis, intact response of bone marrow is necessary for collateral formation in CAD. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
dc.description.sponsorshipHacettepe University Scientific Research Unit
dc.description.sponsorshipAuthors have no conflict of interest. This study was funded by Hacettepe University Scientific Research Unit.
dc.identifier.doi10.1016/j.atherosclerosis.2011.08.045
dc.identifier.endpage854
dc.identifier.issn0021-9150
dc.identifier.issue2
dc.identifier.pmid21943873
dc.identifier.scopusqualityQ1
dc.identifier.startpage851
dc.identifier.urihttps://doi.org/10.1016/j.atherosclerosis.2011.08.045
dc.identifier.urihttps://hdl.handle.net/11486/6689
dc.identifier.volume219
dc.identifier.wosWOS:000298813900080
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofAtherosclerosis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectEndothelial progenitor cells
dc.subjectCoronary artery disease
dc.subjectCoronary collateral
dc.titleThe association between circulating endothelial progenitor cells and coronary collateral formation
dc.typeArticle

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