The enzyme kinetic studies, DNA protection and antioxidant activities of furan/ thiophene-2-carboxamide derivatives

Basit Öğe Kaydı
dc.contributor.authorÇakmak, Sükriye
dc.contributor.authorYenigün, Semiha
dc.contributor.authorOzen, Tevfik
dc.date.accessioned2025-03-23T18:55:11Z
dc.date.available2025-03-23T18:55:11Z
dc.date.issued2024
dc.departmentSinop Üniversitesi
dc.descriptionTUBITAK (221Z330)
dc.description.abstractThree furan and/or thiophene-2-carboxamide compounds, namely N-(furan-2-ylmethyl)thiophene-2-carboxamide (1), N-(furan-2-carbonyl)furan-2-carboxamide (2), and N-(Thiophene-2-ylmethyl)furan-2-carboxamide (3) were investigated the enzyme kinetic studies by urease, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). The inhibition constant (Ki) of Compound (CPD)3 by AChE was determined as 0.10 mM, and the Ki value by BChE was determined as 0.07 mM. In comparison, the Ki value of CPD1 by urease was determined as 0.10 mM. These CPDs were examined for antioxidant activity by the DPPH? scavenging method. CPD3 exhibited 98.93% DPPH scavenging activity compared to ascorbic acid, the positive control group. Furthermore, the DNA-protective activities of the compounds were investigated, and the DNA protection activity of CPD1 was observed to be 78%. The findings suggest that thiophene/furan carboxy amide-containing CPD1 and CPD3 might be exploited as potential structures for evaluating pharmaceuticals with greater potency.
dc.identifier.doi10.32571/ijct.1405155
dc.identifier.doihttps://doi.org/10.32571/ijct.1405155
dc.identifier.endpage142
dc.identifier.issn2602-277X
dc.identifier.issue2
dc.identifier.startpage137
dc.identifier.urihttps://hdl.handle.net/11486/2432
dc.identifier.volume8
dc.language.isoen
dc.publisherIbrahim DEMIRTAS
dc.relation.ispartofInternational Journal of Chemistry and Technology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250323
dc.subjectFuran/thiophene-2-carboxamide
dc.subjectacetylcholinesterase
dc.subjectbutyrylcholinesterase
dc.subjecturease inhibition
dc.subjectDNA-protective activity
dc.titleThe enzyme kinetic studies, DNA protection and antioxidant activities of furan/ thiophene-2-carboxamide derivatives
dc.typeArticle

Dosyalar

Koleksiyon

Öksüz Yayınları