Epicardial adipose tissue thickness predicts descending thoracic aorta atherosclerosis shown by multidetector computed tomography

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dc.authoridOto, Sibel/0000-0003-0171-4200
dc.authoridGurses, Kadri Murat/0000-0003-3904-0985
dc.authoridCanpolat, Ugur/0000-0002-4250-1706
dc.contributor.authorYorgun, Hikmet
dc.contributor.authorCanpolat, Ugur
dc.contributor.authorHazirolan, Tuncay
dc.contributor.authorSunman, Hamza
dc.contributor.authorAtes, Ahmet Hakan
dc.contributor.authorGurses, Kadri Murat
dc.contributor.authorErtugrul, Ozgur
dc.date.accessioned2025-03-23T19:44:29Z
dc.date.available2025-03-23T19:44:29Z
dc.date.issued2012
dc.departmentSinop Üniversitesi
dc.description.abstractHuman epicardial adipose tissue (EAT) is a type of visceral adipose tissue functioning as an endocrine organ by secreting hormones and adipocytokines which have an important role in the atherosclerotic process. In this study, we aimed to assess the relationship between EAT measured by dual source multidetector computed tomography (MDCT) and descending thoracic aorta (DTA) atherosclerosis. A total of 148 patients who underwent MDCT for the evaluation of coronary artery disease were enrolled in this study. Thickness of the EAT was measured on contrast enhanced multiplanar reformat images with parasternal short axis view at basal, mid-ventricular and apical levels and horizontal long axis view. The atherosclerotic plaque was scored from 0 to 4 points by the percentage of the luminal surface at the cross sectional area of proximal, mid and distal segments of descending aorta. Among the study population, 84 (56.8%) were male and age was (mean +/- A standart deviation) 56.9 +/- A 11.7 years. In patients with critical coronary atherosclerosis, DTA atherosclerosis had a significant relationship with EAT (P = 0.012). Multivariate linear regression analysis revealed that in addition to critical coronary stenosis, age and total epicardial fat thickness were associated with aortic atherosclerosis (beta value, 0.058 and 0.035; t value, 4.74 and 2.28, respectively; P < 0.05) after adjustment for traditional cardiovascular risk factors. In this study we demonstrated that atherosclerotic plaque burden of DTA was associated with the amount of EAT thickness among patients with suspected CAD shown by MDCT. Further large scale prospective studies are needed to address the interaction of EAT as well as the mediators of inflammation and adipocytokines with the development of atherosclerotic plaques in aorta and effects on cardiovascular outcomes.
dc.identifier.doi10.1007/s10554-011-9899-x
dc.identifier.endpage919
dc.identifier.issn1569-5794
dc.identifier.issn1573-0743
dc.identifier.issue4
dc.identifier.pmid21637979
dc.identifier.scopusqualityQ2
dc.identifier.startpage911
dc.identifier.urihttps://doi.org/10.1007/s10554-011-9899-x
dc.identifier.urihttps://hdl.handle.net/11486/6949
dc.identifier.volume28
dc.identifier.wosWOS:000304560800024
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Journal of Cardiovascular Imaging
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectEpicardial fat tissue
dc.subjectAortic atherosclerosis
dc.subjectMultidetector computed tomography
dc.titleEpicardial adipose tissue thickness predicts descending thoracic aorta atherosclerosis shown by multidetector computed tomography
dc.typeArticle

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