Whole Genome Sequence-Based Classification of Nonomuraea marmarensis sp. nov., Isolated from Island Soil

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dc.contributor.authorTopkara, Ahmet Ridvan
dc.contributor.authorSaygin, Hayrettin
dc.contributor.authorSaricaoglu, Salih
dc.contributor.authorVeyisoglu, Aysel
dc.contributor.authorTokatli, Ali
dc.contributor.authorGuven, Kiymet
dc.contributor.authorCetin, Demet
dc.date.accessioned2026-04-25T14:20:30Z
dc.date.available2026-04-25T14:20:30Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractActinomycetes are known to produce a vast array of bioactive secondary metabolites with potential therapeutic applications, including antimicrobials, anticancer agents, and enzyme inhibitors. Among these, members of the genus Nonomuraea have received much attention due to their broad ecological importance in nutrient cycling in soil and their ability to produce new bioactive compounds. A novel actinomycetes, designated strain M3C6T, was isolated from soil samples collected on Marmara Island, located in the Istanbul province, aiming to explore the microbial diversity of unexplored habitats, and characterized using a polyphasic approach. The isolate showed chemotaxonomic and morphological features consistent with members of the genus Nonomuraea. The 16S rRNA gene sequence analysis revealed that strain M3C6T shared the highest similarity, at 98.7% sequence identity, to Nonomuraea basaltis 160415T and Nonomuraea turkmeniaca DSM 43926T. However, the ANI and dDDH values between strain M3C6T and these reference strains were fairly low, ranging from 84.0 to 84.6% and 31.8 to 33.7%, respectively, below the generally accepted cutoffs for ANI and DDH that delineate different prokaryotic species. Genomic analysis of strain M3C6T showed that it had a genome size of 10.38 Mbp and a DNA G+C content of 69.5 mol%. Based on these chemotaxonomic, phenotypic, and genomic data, strain M3C6T is classified as a novel species within the genus Nonomuraea, for which the name Nonomuraea marmarensis sp. nov. is proposed. The type strain is M3C6T (= KCTC 49983T = CGMCC 4.8035T). Genomic analyses confirmed the high potential of M3C6T to produce specialized secondary metabolites.
dc.description.sponsorshipOndokuz Mayis University; [PYO.FEN.1904.21.006]
dc.description.sponsorshipThis research was supported by the Ondokuz Mayis University (grant number: PYO.FEN.1904.21.006).
dc.identifier.doi10.3390/taxonomy5010005
dc.identifier.issn2673-6500
dc.identifier.issue1
dc.identifier.orcid0000-0002-7559-8882
dc.identifier.orcid0000-0002-8642-5872
dc.identifier.orcid0000-0002-0013-9024
dc.identifier.orcid0000-0001-5813-1095
dc.identifier.orcid0000-0003-1764-8113
dc.identifier.orcid0000-0002-1406-5513
dc.identifier.orcid0000-0003-1186-4229
dc.identifier.scopus2-s2.0-105002049382
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/taxonomy5010005
dc.identifier.urihttps://hdl.handle.net/11486/8614
dc.identifier.volume5
dc.identifier.wosWOS:001482349600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofTaxonomy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subjectActinomycetes
dc.subjectNonomuraea
dc.subjectisland soil
dc.subjectbiosynthetic gene clusters
dc.subjectwhole genome analysis
dc.subject16S rRNA gene
dc.titleWhole Genome Sequence-Based Classification of Nonomuraea marmarensis sp. nov., Isolated from Island Soil
dc.typeArticle

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