Crystallographic Studies of Dehydration Phenomenon in Methyl 3-hydroxy-2-methyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1λ 6-benzo[e][1,2]thiazine-3-carboxylate
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer/Plenum Publishers
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Methyl 3-hydroxy-2-methyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1 lambda(6)-benzo[e][1,2]thiazine-3-carboxylate was synthesized in single step through in situ bromination of methyl 2-methyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1 lambda(6)-benzo[e][1,2]thiazine-3-carboxylate using dibenzoyl peroxide & N-bromosuccinamide and was crystallized in acetone-ethyl acetate mixture (1:1). However, crystallization in methanol converted the title compound to methyl 3-methoxy-2-methyl-1,1,4-trioxo-1,2,3,4-tetrahydro-1 lambda(6)-benzo[e][1,2]thiazine-3-carboxylate, an unsymmetrical ether. The titled compound C11H11NO6S (3) crystallized in nonoclinic space group P2(1)/c whereas, the compound C12H13NO6S (4) crystallized in triclinic space group P-1. X-ray studies shows that the molecules of 1 are linked into a one-dimensional framework structure by C-H center dot center dot center dot O and O-H center dot center dot center dot O hydrogen bonds, while in 4, intermolecular C-H center dot center dot center dot O and C-H center dot center dot center dot pi hydrogen bonds and a pi center dot center dot center dot pi interaction result in the formation of infinite chains running along the [010] and [001] directions.
Açıklama
Anahtar Kelimeler
1,2-Benzothiazine 1,1-dioxide, Dibenzoylperoxide, N-bromosuccinamide, Dehydration, Unsymmetrical ether
Kaynak
Journal of Chemical Crystallography
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
43
Sayı
12
