Water-soluble binary and ternary palladium() complexes containing amino acids and intercalating ligands: synthesis, characterization, biomolecular interactions and cytotoxicities

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dc.authoridINCI OZBAGCI, Duygu/0000-0002-0483-9642
dc.authoridSahin, Onur/0000-0003-3765-3235
dc.authoridVATAN, Ozgur/0000-0002-7687-3284
dc.authoridAydin, Rahmiye/0000-0003-4944-0181
dc.authoridCinkilic, Nilufer/0000-0002-3595-6286
dc.contributor.authorInci, Duygu
dc.contributor.authorAydin, Rahmiye
dc.contributor.authorVatan, Ozgur
dc.contributor.authorSahin, Onur
dc.contributor.authorCinkilic, Nilufer
dc.date.accessioned2025-03-23T19:35:43Z
dc.date.available2025-03-23T19:35:43Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, six water soluble cationic binary (1-3) palladium() complexes of the type [PdA(2)](NO3)(2)(n - 1)H2O and ternary (4-6) palladium() complexes of the type [PdA(amino acid)](NO3)(n - 1)H2O, where A is 1,10-phenanthroline (phen) (1, 4, 6), 5-methyl-1,10-phenanthroline (5-mphen) (2, 5), and 3,4,7,8-tetramethyl-1,10-phenanthroline (tmphen) (3) and the amino acid is l-tyrosine (tyr) (4, 5) and glycine (gly) (6), have been synthesized and characterized using CHN elemental analyses, ATR-FT-MIR, H-1 NMR and C-13 NMR and single-crystal X-ray diffraction techniques. The interaction of the complexes with calf thymus DNA (CT-DNA) was investigated using electronic absorption spectral, ethidium bromide (EB) and Hoechst 33258 (HO) displacement assays and thermal denaturation. The pUC19 DNA cleavage activity of the complexes was investigated in the absence and presence of external agents by agarose gel electrophoresis. Quenching of the tryptophan and tyrosine residues of bovine serum albumin (BSA) by the complexes was found to be static. Furthermore, the in vitro cytotoxic effect of the complexes was examined on human tumor cell lines (Caco-2, A549, and MCF-7) and healthy cells (BEAS-2B). All the complexes exhibited different cytotoxic activities.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [2211-C]; Research Fund of Uludag University [OUAP (F)-2015/14]
dc.description.sponsorshipWe thank the Research Fund of Uludag University for the financial support given to the research projects (Project Numbers OUAP (F)-2015/14) and the Scientific and Technological Research Council of Turkey (TUBITAK) for Domestic PhD Scholarship intended for Priority Areas of the first author (Code: 2211-C). This study is a part of doctoral thesis in progress of the first author at the Graduate School of Natural and Applied Sciences of Uludag University.
dc.identifier.doi10.1039/c8nj05934a
dc.identifier.endpage4697
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue12
dc.identifier.scopus2-s2.0-85063220833
dc.identifier.scopusqualityQ2
dc.identifier.startpage4681
dc.identifier.urihttps://doi.org/10.1039/c8nj05934a
dc.identifier.urihttps://hdl.handle.net/11486/5915
dc.identifier.volume43
dc.identifier.wosWOS:000462541900003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofNew Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectBovine Serum-Albumin
dc.subjectDouble-Strand Dna
dc.subjectCopper(Ii) Complex
dc.subjectIn-Vitro
dc.subjectSubstituted 1,10-Phenanthrolines
dc.subjectPlatinum(Ii) Complexes
dc.subjectCrystal-Structure
dc.subjectBsa Binding
dc.subjectDerivatives
dc.subjectPhenanthroline
dc.titleWater-soluble binary and ternary palladium() complexes containing amino acids and intercalating ligands: synthesis, characterization, biomolecular interactions and cytotoxicities
dc.typeArticle

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