Effects of Haemodynamic Changes Caused by Different Pneumoperitoneum Pressures on Cerebral Oxygenation in Laparoscopic Cholecystectomy: Prospective Randomised Controlled Trial

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dc.authoridONCU, KIVANC/0000-0001-6052-5640
dc.contributor.authorOncu, Kivanc
dc.contributor.authorSaylan, Sedat
dc.date.accessioned2025-03-23T19:26:47Z
dc.date.available2025-03-23T19:26:47Z
dc.date.issued2024
dc.departmentSinop Üniversitesi
dc.description.abstractObjective: To evaluate the role of different pneumoperitoneum pressure ranges on cerebral oxygenation.Study design: Prospective, randomised controlled trial. Place and Duration of the Study: Karadeniz Technical University, Turkiye, from January to September 2020.Methodology: Seventy patients (aged 18-65 years, ASA I-IIII) scheduled for laparoscopic cholecystectomy were divided into two groups; low pressure (LP, 10-12 mmHg) and high pressure (HP, 13-15 mmHg). The heart rate, peripheral oxygen saturation, systolic, diastolic, and mean arterial pressure, BIS, end-tidal carbon dioxide, and left and right regional cerebral oxygen saturation (rSO2) were recorded during induction, at the beginning, and after 5, 10, 15, 30, 60, and 90th minutes of pneumoperitoneum, after the surgical and anaesthesia procedures.Results: The findings did not demonstrate a significant difference between the haemodynamic parameters of the groups. However, there were differences (fifth [p=0.022], fifteenth minutes [p=0.035], at the end [p=0038] of pneumoperitoneum in right rSO2, and similarly at the end [p=0.038] of pneumoperitoneum in left rSO2 between mean variation of rSO2 when compared to the baseline; cerebral oxygenation was better preserved in LP. While no patient had more than 20% rSO2 reduction in LP, a total of three patients had cerebral desaturation in HP.Conclusion: Although <15 mmHg pressure for pneumoperitoneum was usually well-tolerated by patients, it had been observed that cerebral oxygenation may be affected with this range. The pathophysiological effects of pneumoperitoneum and possible consequences of this situation should be considered while performing laparoscopy.
dc.identifier.doi10.29271/jcpsp.2024.01.16
dc.identifier.endpage21
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue1
dc.identifier.pmid38185954
dc.identifier.scopusqualityQ2
dc.identifier.startpage16
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2024.01.16
dc.identifier.urihttps://hdl.handle.net/11486/4781
dc.identifier.volume34
dc.identifier.wosWOS:001140254200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherColl Physicians & Surgeons Pakistan
dc.relation.ispartofJcpsp-Journal of the College of Physicians and Surgeons Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectCerebrovascular circulation
dc.subjectHaemodynamics
dc.subjectLaparoscopic cholecystectomy
dc.subjectNear-infrared spectroscopy
dc.subjectPneumoperi-toneum
dc.titleEffects of Haemodynamic Changes Caused by Different Pneumoperitoneum Pressures on Cerebral Oxygenation in Laparoscopic Cholecystectomy: Prospective Randomised Controlled Trial
dc.typeArticle

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