Synthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5-Dihydro-1H-1,2,4-Triazol-5-One Derivatives

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dc.contributor.authorYüksek, Haydar
dc.contributor.authorAkyıldırım, Onur
dc.contributor.authorYola, Mehmet Lütfi
dc.contributor.authorKol, Özlem Gürsoy
dc.contributor.authorÇelebier, Mustafa
dc.contributor.authorKart, Didem
dc.date.accessioned2015-06-04T06:12:48Z
dc.date.available2015-06-04T06:12:48Z
dc.date.issued2013
dc.description.abstractA series of compounds derived from 4,5-dihydro-1H-1,2,4-triazol-5-one were synthesized and characterized by spectral data. The 12 new compounds were analyzed for their potential in vitro antioxidant activities by three different methods. Compound 4f showed the best activity for the iron binding. In addition, the compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide in non-aqueous solvents. The RP-HPLC capacity factors (k0) of the series were also determined on a C18 column, with methanol/water as the mobile phase. The correlation between log k0 with the percentage of methanol in the mobile phase was used for the determination of the log kw values for these compounds. The antimicrobial activities of these compounds were also screened against bacteria and yeast.
dc.identifier.citationYüksek, H.; Akyıldırım, O.; Yola, M. L.; Kol, Ö. G.; Çelebier, M.; Kart, D. "Synthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5-Dihydro-1H-1,2,4-Triazol-5-One Derivatives" Archiv der Pharmazie-Chemistry in Life Sciences, 346, 470-480, 2013.
dc.identifier.doi10.1002/ardp.201300048
dc.identifier.scopus2-s2.0-84879295988
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1002/ardp.201300048/epdf
dc.identifier.urihttps://hdl.handle.net/11486/1051
dc.identifier.urihttps://doi.org/10.1002/ardp.201300048
dc.identifier.wosWOS:000320473000006
dc.language.isoen
dc.publisherArchiv der Pharmazie-Chemistry in Life Sciences
dc.relation.publicationcategoryMakale - Kategorisiz
dc.subject1,2,4-Triazol-5-one
dc.subjectAcidity
dc.subjectAntimicrobial activity
dc.subjectAntioxidant activity
dc.subjectLog kw
dc.titleSynthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5-Dihydro-1H-1,2,4-Triazol-5-One Derivatives
dc.typeArticle

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