Synthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5-Dihydro-1H-1,2,4-Triazol-5-One Derivatives
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Archiv der Pharmazie-Chemistry in Life Sciences
Erişim Hakkı
Özet
A series of compounds derived from 4,5-dihydro-1H-1,2,4-triazol-5-one were synthesized and characterized by spectral data. The 12 new compounds were analyzed for their potential in vitro antioxidant activities by three different methods. Compound 4f showed the best activity for the iron binding. In addition, the compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide in non-aqueous solvents. The RP-HPLC capacity factors (k0) of the series were also determined on a C18 column, with methanol/water as the mobile phase. The correlation between log k0 with the percentage of methanol in the mobile phase was used for the determination of the log kw values for these compounds. The antimicrobial activities of these compounds were also screened against bacteria and yeast.
Açıklama
Anahtar Kelimeler
1,2,4-Triazol-5-one, Acidity, Antimicrobial activity, Antioxidant activity, Log kw
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Yüksek, H.; Akyıldırım, O.; Yola, M. L.; Kol, Ö. G.; Çelebier, M.; Kart, D. "Synthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5-Dihydro-1H-1,2,4-Triazol-5-One Derivatives" Archiv der Pharmazie-Chemistry in Life Sciences, 346, 470-480, 2013.
