Novel zinc compound with thiosemicarbazone of glyoxylic acid: Synthesis, crystal structure, and bioactivity properties

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dc.authoridHuseynova, Mansura/0000-0002-1534-6819
dc.authoridSahin, Onur/0000-0003-3765-3235
dc.authoridFarzaliyev, Vagif/0009-0004-4301-475X
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.contributor.authorHuseynova, Mansura
dc.contributor.authorFarzaliyev, Vaqif
dc.contributor.authorMedjidov, Ajdar
dc.contributor.authorAliyeva, Mahizar
dc.contributor.authorTaslimi, Parham
dc.contributor.authorSahin, Onur
dc.contributor.authorYalcin, Bahattin
dc.date.accessioned2025-03-23T19:39:35Z
dc.date.available2025-03-23T19:39:35Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractReaction of zinc nitrate with thiosemicarbazone of glyoxylic acid (H(2)GAT) leads to the formation of the new complex that have been characterized by spectroscopic methods. Crystal structure of the compound Zn3C18H34N18O17S6 (1) was determined using single crystal X-ray diffraction methods. Single crystal X-ray measurements showed that the complex crystallized in a triclinic system with the space group P-1. The structure of complex 1 presents distorted octahedral geometry around the zinc ion centre. In the crystal structure, Zn(II) ion is coordinated by two nitrogen, two oxygen and two sulfur atoms from two different thiosemicarbazone of glyoxylic acid and two oxygen atoms from two different water molecules. Thermogravimetry shows four steps of decomposition in the temperature range 225-990 degrees C. This complex was an inhibitor of butyrylcholinesterase (BChE), cytosolic carbonic anhydride I and II isoforms (hCA I and II) and acetylcholinesterase (AChE) enzymes for complex 1 with Ki values of 0.95 +/- 0.10 mu M for hCA I, 1.54 +/- 0.24 mu M for hCA II, 25.98 +/- 2.44 mu M for BChE, 166.21 +/- 13.63 mu M for alpha-glycosidase and 18.53 +/- 1.36 mu M for AChE, respectively. (C) 2019 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.molstruc.2019.127082
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85072303556
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2019.127082
dc.identifier.urihttps://hdl.handle.net/11486/6367
dc.identifier.volume1200
dc.identifier.wosWOS:000496810900029
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectZn-complex
dc.subjectThiosemicarbazones
dc.subjectCrystal structure
dc.subjectEnzyme inhibition
dc.titleNovel zinc compound with thiosemicarbazone of glyoxylic acid: Synthesis, crystal structure, and bioactivity properties
dc.typeArticle

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