Vitamin D: An Overlooked Parameter in Studies of Depression Using Optic Coherence Tomography

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dc.contributor.authorTurhan, Nur Ozgedik
dc.contributor.authorArisoy, Ozden
dc.contributor.authorUlas, Fatih
dc.contributor.authorBugdayci, Guler
dc.contributor.authorGuelner, Melek Altintas
dc.date.accessioned2025-03-23T19:26:46Z
dc.date.available2025-03-23T19:26:46Z
dc.date.issued2024
dc.departmentSinop Üniversitesi
dc.description.abstractIntroduction: The relationship between depression and inflammation and the resulting vascular/neuronal damage have been demonstrated in recent studies. In this study we aimed to investigate inflammation and the possible degeneration that can be caused by depression and accompanying vitamin D deficiency using a non-invasive imaging method of optical coherence tomography (OCT). Methods:Twenty-four healthy controls and 42 drug free major depressive patients matched for age, sex and eye measurements were compared in terms of vitamin D, C Reactive Protein (CRP) and OCT parameters. The Hamilton Depression Rating Scale (HAM -D), The Clinical Global Impressions Scale (CGI) and Global Assessment of Functioning Scale (GAF) were used to assess disease severity. Results: CRP level and choroidal thickness in the major depression group were significantly higher than the healthy controls. Vitamin D level and the ganglion cell layer (GCL) volume was significantly lower in the major depression group compared to healthy controls. Positive correlation was found between HAM -D and CRP in major depressive patients; a negative correlation was found between current attack duration and GCL volume. CGI was positively correlated with CRP and HAM -D. GAS was negatively correlated with CRP and HAM -D. Conclusion: It has been shown that major depression might be an inflammatory disorder with possible degenerative processes observed with OCT and CRP measurements. But longitudinal follow up studies are needed to demonstrate a cause and effect relationship.
dc.description.sponsorshipAbant Idot;zzet Baysal University Scientific Research Project Commission
dc.description.sponsorshipIt was supported by Abant & Idot;zzet Baysal University Scientific Research Project Commission.
dc.identifier.doi10.29399/npa.28369
dc.identifier.endpage72
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue1
dc.identifier.pmid38496230
dc.identifier.scopusqualityQ3
dc.identifier.startpage66
dc.identifier.urihttps://doi.org/10.29399/npa.28369
dc.identifier.urihttps://hdl.handle.net/11486/4778
dc.identifier.volume61
dc.identifier.wosWOS:001181385500016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectC reactive protein
dc.subjectmajor depression
dc.subjectoptical coherence tomography
dc.subjectvitamin D
dc.titleVitamin D: An Overlooked Parameter in Studies of Depression Using Optic Coherence Tomography
dc.typeArticle

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