Synthesis, Characterization of a-Cyanochalcone Compounds and Determination of Their Antibacterial, Antifungal, and Antioxidant Activities

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dc.contributor.authorAslan, Hakan
dc.contributor.authorAvsar, Cumhur
dc.date.accessioned2026-04-25T14:13:25Z
dc.date.available2026-04-25T14:13:25Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, the Knoevenagel condensation reactions of 3-(heteroaryl)-3-oxopropanenitriles and various aromatic/heteroaromatic aldehydes via L-proline were performed. In these reactions, α-cyanochalcone compounds were obtained in mid-good yields. Spectroscopic techniques were used to clarify the compounds' structures. Both the well-diffusion method and the minimum inhibitory concentration (MIC) method were used to assess the antibacterial and antifungal properties of all products. Compound 1c, containing the pyridin-3-yl group, exhibited broad-spectrum properties by acting against all bacteria and fungi tested. The antioxidant activities of the compounds were tested by a DPPH radical scavenging assay, and according to the results of antioxidant activities, the most effective compound among all was found to be 1c. It is possible to say that compounds 1b and 1d also have moderate antioxidant activity. © 2025, Adiyaman University. All rights reserved.
dc.description.sponsorshipSinop Üniversitesi, (FEF-1901-21-001)
dc.identifier.doi10.37094/adyujsci.1584171
dc.identifier.endpage16
dc.identifier.issn2147-1630
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105010253505
dc.identifier.scopusqualityQ4
dc.identifier.startpage1
dc.identifier.trdizinid1342487
dc.identifier.urihttps://doi.org/10.37094/adyujsci.1584171
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1342487
dc.identifier.urihttps://hdl.handle.net/11486/8079
dc.identifier.volume15
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAdiyaman University
dc.relation.ispartofAdiyaman University Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260420
dc.subjectAntimicrobial activity
dc.subjectAntioxidant activity
dc.subjectKnoevenagel condensation
dc.subjectα-cyanochalcone
dc.titleSynthesis, Characterization of a-Cyanochalcone Compounds and Determination of Their Antibacterial, Antifungal, and Antioxidant Activities
dc.title.alternativea-Siyanokalkon Bilesiklerinin Sentezi, Karakterizasyonu ve Antibakteriyel, Antifungal ve Antioksidan Aktivitelerinin Belirlenmesi
dc.typeArticle

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