Registries of cases with neural tube defects in Denizli, Turkey, 2004-2010

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dc.contributor.authorTomatir, A. G.
dc.contributor.authorVural, B. Kiray
dc.contributor.authorAcikbas, I.
dc.contributor.authorAkdag, B.
dc.date.accessioned2025-03-23T19:25:50Z
dc.date.available2025-03-23T19:25:50Z
dc.date.issued2014
dc.departmentSinop Üniversitesi
dc.description.abstractNeural tube defects (NTD) are among the most common congenital abnormalities, with an incidence of 3 per 1000 live births in Turkey. In a study of major congenital abnormalities in the city of Denizli, Turkey, abnormalities of the central nervous system are particularly common (31.1%). The objective of this study was to develop a registry of cases with NTDs in Denizli. Cases that had been diagnosed with NTD between January 2004 and September 2010 in State Hospitals of Central Denizli were retrospectively examined. The diagnoses were established based on the ICD-10 criteria. A total of 250 subjects with NTD were identified, including 123 (49.2%) females and 127 (50.8%) males with a mean age of 13.72 +/- 15.62 years (age range 1-81 years). Interestingly, spina bifida constituted a significant percentage of the cases (149 cases; 59.6%). In addition, 10 (4.0%) cases had hydrocephalus plus spina bifida. The second most common diagnosis was microcephaly, which included 70 cases (28.0%). Encephalocele was observed in only 2 cases (0.8%). Development of NTD is influenced by nutrition, socioeconomic factors, and the use of folic acid during the peri-conceptional period. Studies examining the effect of these factors on NTD in Turkey and a review of primary prevention measures are necessary.
dc.identifier.doi10.4238/2014.October.20.30
dc.identifier.endpage8543
dc.identifier.issn1676-5680
dc.identifier.issue4
dc.identifier.pmid25366748
dc.identifier.scopusqualityQ4
dc.identifier.startpage8537
dc.identifier.urihttps://doi.org/10.4238/2014.October.20.30
dc.identifier.urihttps://hdl.handle.net/11486/4577
dc.identifier.volume13
dc.identifier.wosWOS:000345119800048
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFunpec-Editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectFolic acid
dc.subjectNeural tube defect
dc.subjectRegistry
dc.subjectSpina bifida
dc.subjectTurkey
dc.titleRegistries of cases with neural tube defects in Denizli, Turkey, 2004-2010
dc.typeArticle

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