Cardiovascular risk and coronary atherosclerotic plaques detected by multidetector computed tomography: Framingham and SCORE risk models underestimate coronary atherosclerosis in the symptomatic low-risk Turkish population

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dc.authoridOto, Sibel/0000-0003-0171-4200
dc.authoridCanpolat, Ugur/0000-0002-4250-1706
dc.authoridGurses, Kadri Murat/0000-0003-3904-0985
dc.contributor.authorCanpolat, Ugur
dc.contributor.authorYorgun, Hikmet
dc.contributor.authorAytemir, Kudret
dc.contributor.authorHazirolan, Tuncay
dc.contributor.authorKaya, Ergun Baris
dc.contributor.authorAtes, Ahmet Hakan
dc.contributor.authorDural, Muhammed
dc.date.accessioned2025-03-23T19:34:18Z
dc.date.available2025-03-23T19:34:18Z
dc.date.issued2012
dc.departmentSinop Üniversitesi
dc.description.abstractObjective In this study, we investigated the association between cardiovascular (CV) risk factors and coronary atherosclerotic plaque (CAP) burden/subtypes shown by multidetector computed tomography in symptomatic patients free of known coronary artery disease (CAD). Methods In 662 consecutive outpatients (56.9 +/- 10.7 years, 50.8% men) without known CAD, 64-slice multidetector computed tomography coronary angiography was performed for detection of CAD. Risk estimation for CV outcomes was assessed using the Systematic Coronary Risk Evaluation (SCORE) and the Framingham Risk Score (FRS). Logistic regression analysis was used to evaluate the association of CV risk factors with the prevalence/extent of CAP. Results CAP was detected in 318 (48.0%) individuals. Male sex, older age, hypertension, diabetes mellitus, smoking, and dyslipidemia all increased the likelihood of the presence of CAP in univariate analysis (P < 0.001). Older age, male sex, dyslipidemia, and diabetes mellitus independently increased the likelihood of the presence of CAP in multivariate analysis (P < 0.005). Multinominal logistic regression analysis showed an association with older age, male sex, dyslipidemia, and smoking for noncalcified plaques; with older age, male sex, diabetes, and dyslipidemia for mixed plaques; and with older age and male sex for calcified plaque. Patients with low FRS and SCORE showed a large number of CAPs (33.8 and 40.4%), although CAP was more prevalent in the high-risk groups (67 and 78%, respectively). Conclusion CV risk stratification using only risk factor-based scores is a weak discriminator of the overall CAP burden in individual patients. Many patients with low FRS or SCORE with substantial CAP might be undertreated or not treated at all. Coron Artery Dis 23:195-200 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
dc.identifier.doi10.1097/MCA.0b013e3283511608
dc.identifier.endpage200
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue3
dc.identifier.pmid22327064
dc.identifier.scopusqualityQ3
dc.identifier.startpage195
dc.identifier.urihttps://doi.org/10.1097/MCA.0b013e3283511608
dc.identifier.urihttps://hdl.handle.net/11486/5647
dc.identifier.volume23
dc.identifier.wosWOS:000302773100009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCoronary Artery Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectcardiovascular risk
dc.subjectcoronary atherosclerotic plaque
dc.subjectmultidetector computed tomography
dc.titleCardiovascular risk and coronary atherosclerotic plaques detected by multidetector computed tomography: Framingham and SCORE risk models underestimate coronary atherosclerosis in the symptomatic low-risk Turkish population
dc.typeArticle

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