Novel heteroleptic metal cation complexes of anisic acid/N, N-diethylnicotinamide ligands and biological applications

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dc.contributor.authorCataldag, Esra
dc.contributor.authorKose, Dursun Ali
dc.contributor.authorOzluk, Gizem
dc.contributor.authorSahin, Onur
dc.date.accessioned2026-04-25T14:19:58Z
dc.date.available2026-04-25T14:19:58Z
dc.date.issued2026
dc.departmentSinop Üniversitesi
dc.description.abstractFive different heteroleptic complex structures were synthesized by the coordination of anionic p-methoxybenzoate (anisate) and neutral N,N-diethylnicotinamide (niketamide) ligands to transition metal cations (Mn2+, Co2+, Ni2+, Cu2+ and Zn2+). The similarity of the spectroscopic and thermal properties of the Ni2+ cation-centered complex, whose single crystal structure was solved, to other complexes supports the suggestion that the structures are isostructural. Chemical composition analysis and other spectroscopic analysis results support the idea that the Cu2+ cation-centered structure, unlike the others, is in five-fold coordination. It is predicted that the six-fold coordination complexes (Mn2+, Co2+, Ni2+ and Zn2+) are coordinated by two anisate anions, two neutral nicotinamide ligands, and two crystal waters, while the Cu2+ structure is coordinated with a single crystal water content. It was also determined that the Co2+ and Zn2+ cation complexes possess hydrate waters bound to the coordination sphere by hydrogen bonds. Thermal decomposition curves support the presence of hydrate molecules within the structures. The antibacterial and antifungal properties of the structurally characterized molecules were investigated against biological agents such as Escherichia coliATCC 25,922, K. pneumoniae K6 ATCC 700,603, E. faecalis ATCC 29,212, S. epidermidis ATCC 12,228, and C. krusei ATCC 6258 using the disk diffusion method. The effectiveness of the Zn2+ complex compound against ampicillin-resistant K. pneumoniae strains can be considered significant.
dc.description.sponsorshipHitit University Scientific Research Projects Coordination [FEF19004.23.002]
dc.description.sponsorshipProject number FEF19004.23.002 was supported by Hitit University Scientific Research Projects Coordination.
dc.identifier.doi10.1016/j.molstruc.2025.145219
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.orcid0000-0003-1630-1222
dc.identifier.orcid0000-0003-3765-3235
dc.identifier.scopus2-s2.0-105027201442
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2025.145219
dc.identifier.urihttps://hdl.handle.net/11486/8298
dc.identifier.volume1357
dc.identifier.wosWOS:001659814100004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subjectP-methoxybenzoate
dc.subjectAnisate
dc.subjectN-diethylnicotinamide
dc.subjectHeteroleptic complexes
dc.subjectBiological activity
dc.subjectStructural analysis
dc.titleNovel heteroleptic metal cation complexes of anisic acid/N, N-diethylnicotinamide ligands and biological applications
dc.typeArticle

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