Diazenyl-hydrazone functionalized silatrane hybrids: Integrating structural precision for Al (III) sensing and anticancer activity

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dc.contributor.authorSingh, Gurjaspreet
dc.contributor.authorHeena
dc.contributor.authorMeral, Seher
dc.contributor.authorMarkan, Pallavi
dc.contributor.authorKaur, Harshbir
dc.contributor.authorGill, Baljinder Singh
dc.contributor.authorBaliyan, Deepanjali
dc.date.accessioned2026-04-25T14:19:58Z
dc.date.available2026-04-25T14:19:58Z
dc.date.issued2026
dc.departmentSinop Üniversitesi
dc.description.abstractThis manuscript investigates the synthesis and potential of a silatrane-tethered hydrazone derivative as a multifunctional compound capable of selective metal ion sensing, anticancer activity. The synthesized compound demonstrated high sensitivity and selectivity for Al(III) through UV-Vis and fluorescence spectroscopy with 18.73 and 3.46 nM LOD values, respectively, highlighting its effectiveness as a chemosensor. Additionally, both in-vitro and in-silico studies confirmed its promising anticancer properties. The integration of the silatrane framework with the hydrazone moiety enhanced the stability and optical properties of the compound, positioning it as a versatile candidate for addressing key challenges in environmental monitoring and therapeutic interventions. The results indicate that the silatrane-tethered hydrazone holds significant promise for applications in metal ion detection, cancer treatment, providing a foundation for further exploration and development of multifunctional systems with dual sensing and therapeutic roles.
dc.description.sponsorshipDST [SR/FST/CSII-036]
dc.description.sponsorshipThe author would like to thank DST FIST-2015, SR/FST/CSII-036 for providing necessary financial assistance.
dc.identifier.doi10.1016/j.molstruc.2025.144486
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.orcid0000-0003-0660-4721
dc.identifier.orcid0000-0002-8627-420X
dc.identifier.orcid0000-0002-3901-5205
dc.identifier.orcid0000-0002-6090-8809
dc.identifier.orcid0000-0002-6309-8936
dc.identifier.scopus2-s2.0-105019640048
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2025.144486
dc.identifier.urihttps://hdl.handle.net/11486/8294
dc.identifier.volume1352
dc.identifier.wosWOS:001606572700004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subjectAl(III) Detection
dc.subjectAnticancer Activity
dc.subjectIn-vitro Studies
dc.subjectIn-silico Studies
dc.subjectSilatrane
dc.titleDiazenyl-hydrazone functionalized silatrane hybrids: Integrating structural precision for Al (III) sensing and anticancer activity
dc.typeArticle

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