A new pyrimidine-derived ligand, N-pyrimidine oxalamic acid, and its Cu(II), Co(II), Mn(II), Ni(II), Zn(II), Cd(II), and Pd(II) complexes: synthesis, characterization, electrochemical properties, and biological activity

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dc.authoridCELEBI, METIN/0000-0003-1475-8878
dc.authoridLevent, Abdulkadir/0000-0001-5792-419X
dc.authoridSenturk, Zuhre/0000-0002-0356-9345
dc.contributor.authorSonmez, Mehmet
dc.contributor.authorCelebi, Metin
dc.contributor.authorLevent, Abdulkadir
dc.contributor.authorBerber, Ismet
dc.contributor.authorSenturk, Zuehre
dc.date.accessioned2025-03-23T19:35:28Z
dc.date.available2025-03-23T19:35:28Z
dc.date.issued2010
dc.departmentSinop Üniversitesi
dc.description.abstractA new heterocyclic compound N-(5-benzoyl-2-oxo-4-phenyl-2H-pyrimidin-1-yl)-oxalamic acid has been synthesized from N-amino pyrimidine-2-one and oxalylchloride. Bis-chelate complexes of the ligand were prepared from acetate/chloride salts of Cu(II), Co(II), Mn(II), Ni(II), Zn(II), Cd(II), and Pd(II) in methanol. The structures of the ligand and its metal complexes were characterized by microanalyses, IR, AAS, NMR, API-ES, UV-Vis spectroscopy, magnetic susceptibility, and thermogravimetric analyses. An octahedral geometry has been suggested for all the complexes, except for Pd(II) complex, in which the metal center is square planar. Each ligand binds using C(2)=O, HN, and carboxylate. The cyclic voltammograms of the ligand and the complexes are also discussed. The new synthesized compounds were evaluated for antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi using the microdilution procedure. The Cu(II) complex displayed selective and effective antibacterial activity against one Gram-positive spore-forming bacterium (Bacillus cereus ATCC 7064), two Gram-positive bacteria (Staphylococcus aureus ATCC 6538 and S. aureus ATCC 25923) at 40-80 mu g mL-1, but poor activity against Candida species. The Cu(II) complex might be a new antibacterial agent against Gram-positive bacteria.
dc.description.sponsorshipScientific and Research Council of Turkey [TBAG 105T145]
dc.description.sponsorshipWe are grateful to Scientific and Research Council of Turkey (TBAG 105T145) for the support of this research.
dc.identifier.doi10.1080/00958971003646506
dc.identifier.endpage860
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue5
dc.identifier.scopus2-s2.0-77749320321
dc.identifier.scopusqualityQ3
dc.identifier.startpage848
dc.identifier.urihttps://doi.org/10.1080/00958971003646506
dc.identifier.urihttps://hdl.handle.net/11486/5875
dc.identifier.volume63
dc.identifier.wosWOS:000275276500010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectN-aminopyrimidine
dc.subjectMetal complexes
dc.subjectCyclic voltammetry
dc.subjectBiological activity
dc.titleA new pyrimidine-derived ligand, N-pyrimidine oxalamic acid, and its Cu(II), Co(II), Mn(II), Ni(II), Zn(II), Cd(II), and Pd(II) complexes: synthesis, characterization, electrochemical properties, and biological activity
dc.typeArticle

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