Degradation and ecotoxicity of favipiravir and oseltamivir in the presence of microplastics during ozonation and catalytic ozonation of synthetic municipal wastewater effluents

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dc.authoridBilgin-Saritas, Nilay/0000-0001-9400-5344
dc.contributor.authorDogruel, Serdar
dc.contributor.authorChavoshi, Nasim
dc.contributor.authorBilgin-Saritas, Nilay
dc.contributor.authorKhataee, Alireza
dc.contributor.authorTopuz, Emel
dc.contributor.authorPehlivanoglu, Elif
dc.date.accessioned2025-03-23T19:47:09Z
dc.date.available2025-03-23T19:47:09Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractBackgroundFavipiravir (FAV) and oseltamivir (OSE) are antiviral agents developed against influenza and they were repurposed against SARS-CoV-2 during the COVID-19 pandemic. This study evaluated the potential of ozonation and catalytic ozonation as tertiary treatment approaches for removing FAV and OSE from municipal wastewaters, both in the presence and absence of microplastics (MPs), while comparing the ecotoxicity of untreated and treated secondary effluents to predict the ecotoxicological effects of these technologies during municipal wastewater treatment.ResultsAt an initial antiviral concentration of 50 mu g L-1, ozonation at pH 7 with a specific ozone dose of 0.6 mg O3 (mg DOC)-1 yielded FAV and OSE removals of 84 and 64%, respectively, while the presence of catalyst or MPs decreased the degradation rate by 30-40%. Raising the pH to 10 had minimal impact on FAV abatement, but improved OSE reduction by 21%. Acute toxicity tests using Vibrio fischeri demonstrated that simultaneous ozonation of the analytes led to the accumulation of transformation products (TPs) of FAV and OSE, with their combined effect almost equal to that of the original compounds. Reproduction toxicity tests indicated that TPs of antiviral drugs generated during ozonation were less toxic to Enchytraeus crypticus than the parent chemicals.ConclusionOzonation proved to be a viable option for upgrading existing wastewater treatment facilities, serving as a complementary treatment to minimize the release of antivirals from municipal secondary effluents and reduce their inhibitory effect on earthworm reproduction, thereby enhancing the reuse potential of treated wastewater for irrigation. (c) 2025 The Author(s). Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
dc.description.sponsorshipTrkiye Bilimsel ve Teknolojik Arascedil;timath;rma Kurumu [121Y383]; Scientific and Technological Research Council of Turkey (TUBITAK) [MYL-2023-44496]; Scientific Research Projects Coordination Unit of Istanbul Technical University
dc.description.sponsorshipThis study was financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project #121Y383) and Scientific Research Projects Coordination Unit of Istanbul Technical University (ITU-BAP, Project #MYL-2023-44496).
dc.identifier.doi10.1002/jctb.7831
dc.identifier.issn0268-2575
dc.identifier.issn1097-4660
dc.identifier.scopus2-s2.0-85219722620
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jctb.7831
dc.identifier.urihttps://hdl.handle.net/11486/7295
dc.identifier.wosWOS:001425821200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Chemical Technology and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectfavipiravir
dc.subjectoseltamivir
dc.subjectozonation
dc.subjectcatalytic ozonation
dc.subjectmicroplastics
dc.subjectecotoxicity
dc.titleDegradation and ecotoxicity of favipiravir and oseltamivir in the presence of microplastics during ozonation and catalytic ozonation of synthetic municipal wastewater effluents
dc.typeArticle

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