Identification of Hb Hamadan Mutation (β56 GGC→CGC, (D7) Gly→Arg) which was detected in Cukurova Region for the First Time with Microarray Method

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dc.contributor.authorAriyurek, Sedefgul Yuzbasioglu
dc.contributor.authorYildiz, Sule Menziletoglu
dc.contributor.authorAksoy, Kiymet
dc.date.accessioned2025-03-23T19:47:55Z
dc.date.available2025-03-23T19:47:55Z
dc.date.issued2009
dc.departmentSinop Üniversitesi
dc.description.abstractHemoglobin Hamadan is the result of a glycine to arginine change due to GGC. CGC mutation at codon 56 of the beta globin gene. Until today, together with HbS which is the most common mutation in Turkey, fourty nine abnormal hemoglobin mutations have been reported such as rarely observed Hb Hamadan which does not show any clinical symptom. In this study, for the first time, we designed a reporter to Hb Hamadan for Nanogen microarray instrument, by using the base change causing to the mutation of a case which was determined to have an abnormal hemoglobin by sequence analysis. Heterozygous Hemoglobin Hamadan and Hemoglobin Hamadan combined with IVS I-110 mutation was found by using the designed reporter.
dc.identifier.endpage259
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage256
dc.identifier.urihttps://hdl.handle.net/11486/7447
dc.identifier.volume34
dc.identifier.wosWOS:000274244400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isotr
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectHemoglobin Hamadan
dc.subjectmicroarray
dc.subjectprobe design
dc.titleIdentification of Hb Hamadan Mutation (β56 GGC→CGC, (D7) Gly→Arg) which was detected in Cukurova Region for the First Time with Microarray Method
dc.typeArticle

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