Identification of Hb Hamadan Mutation (β56 GGC→CGC, (D7) Gly→Arg) which was detected in Cukurova Region for the First Time with Microarray Method
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Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
Walter De Gruyter Gmbh
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Hemoglobin Hamadan is the result of a glycine to arginine change due to GGC. CGC mutation at codon 56 of the beta globin gene. Until today, together with HbS which is the most common mutation in Turkey, fourty nine abnormal hemoglobin mutations have been reported such as rarely observed Hb Hamadan which does not show any clinical symptom. In this study, for the first time, we designed a reporter to Hb Hamadan for Nanogen microarray instrument, by using the base change causing to the mutation of a case which was determined to have an abnormal hemoglobin by sequence analysis. Heterozygous Hemoglobin Hamadan and Hemoglobin Hamadan combined with IVS I-110 mutation was found by using the designed reporter.
Description
Keywords
Hemoglobin Hamadan, microarray, probe design
Journal or Series
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi
WoS Q Value
Q4
Scopus Q Value
Q3
Volume
34
Issue
4
