Electrophysiological and histopathological effects of mesenchymal stem cells in treatment of experimental rat model of sciatic nerve injury

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dc.authoridALTUN, Adnan/0000-0002-1328-6349
dc.authoridKocabicak, Ersoy/0000-0003-3445-1734
dc.authoridGenc, Eyup/0000-0002-7451-0578
dc.contributor.authorYarar, Ercan
dc.contributor.authorKuruoglu, Enis
dc.contributor.authorKocabicak, Ersoy
dc.contributor.authorAltun, Adnan
dc.contributor.authorGenc, Eyup
dc.contributor.authorOzyurek, Hamit
dc.contributor.authorKefeli, Mehmet
dc.date.accessioned2025-03-23T19:48:48Z
dc.date.available2025-03-23T19:48:48Z
dc.date.issued2015
dc.departmentSinop Üniversitesi
dc.description.abstractAim: The aim of this study was to evaluate electrophysiological and histopathological effects of mesenchymal stem cells in treatment of sciatic nerve injury. Material and methods: Thirty-two female Spraque-Dawley rat were used in this study. Eight rats were used as a reference group in electrophysiological analysis for evaluation of non-injured nerve recordings (Control Group). Twenty-four rats were used for experimental evaluation. Twelve rats were anastomosed without treatment with mesenchymal stem cells (Sham Group) and twelve other rats were anastomosed and treated with mesenchymal stem cells (Stem Cell Group). Surgicel and bioglue were used in anastomosed line in both Groups. Eight weeks after the surgery, electrophysiological evaluation of rats was performed and, then, rats were decapitated under anesthesia and specimens including sciatic nerves and anastomosed line were taken for histopathological evaluation. Electromyography and nerve conduction velocity testing and histopathological scoring including rate of Wallerian degeneration, and neuroma and scar formation were evaluated for both Groups. Results: There were no statistically significant differences between Sham and Stem Cell Groups with respect to histopathological evaluation. However, nerve conduction velocity showed significant difference between groups (P = 0.001). Nerve conduction velocity was significantly improved in Stem Cell Group when compared to Sham Group. Conclusion: In this study, based on nerve conduction velocity data, it was concluded that treatment with mesenchymal stem cells during end-to-end anastomosis improves functional regeneration.
dc.identifier.endpage8784
dc.identifier.issn1940-5901
dc.identifier.issue6
dc.identifier.pmid26309529
dc.identifier.scopusqualityN/A
dc.identifier.startpage8776
dc.identifier.urihttps://hdl.handle.net/11486/7658
dc.identifier.volume8
dc.identifier.wosWOS:000359295600047
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectMesenchymal stem cells
dc.subjectexperimental sciatic nerve injury
dc.subjectnerve conduction velocity
dc.subjectscar tissue
dc.titleElectrophysiological and histopathological effects of mesenchymal stem cells in treatment of experimental rat model of sciatic nerve injury
dc.typeArticle

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