A practical tool for predicting outcomes in essential thrombocythemia: Triple A risk model and beyond

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dc.contributor.authorSonmez, Ozge
dc.contributor.authorOyur, Esiyla
dc.contributor.authorHindilerden, Ipek Yonal
dc.contributor.authorHindilerden, Fehmi
dc.contributor.authorSonmez, Mehmet
dc.contributor.authorKarismaz, Abdulkadir
dc.contributor.authorAtli, Zeynep
dc.date.accessioned2026-04-25T14:20:16Z
dc.date.available2026-04-25T14:20:16Z
dc.date.issued2026
dc.departmentSinop Üniversitesi
dc.description.abstractThe management of essential thrombocythemia (ET) relies on risk stratification; therefore, easily applicable risk scores with improved prognostic value are in demand. The Triple A risk score is a novel model incorporating age, absolute neutrophil, and absolute lymphocyte counts (AAA model). In this study, we aimed to evaluate the predictive performance of Triple A score in ET for survival and its complications in an independent cohort, in addition to refining the model by incorporating absolute monocyte count and neutrophil-to-lymphocyte ratio (NLR). Demographic, clinical, and laboratory data of 565 patients with ET were retrospectively collected. Based on Triple A score, 250 patients were classified as low risk, 228 as intermediate-1 risk, 37 as intermediate-2 risk, and 50 as high risk. Over a median follow-up of 6 years, 10.3% patients developed thrombosis, 4.4% experienced bleeding, 5.1% had post-ET myelofibrosis, and 10.9% died. There were significant differences in overall survival and thrombosis-free survival across risk groups. Monocytosis (>0.8 & times; 10(9)/L) was associated with increased mortality and its prevalence increased progressively with higher Triple A scores. Elevated NLR was also linked to a higher risk of mortality, and moreover, NLR-monocyte-age-based risk score demonstrated significant differences in survival risk. Consequently, Triple A score is an easy-to-use and reliable tool for predicting survival and thrombosis in ET. Incorporating monocytosis into Triple A (AAA+A model) may further enhance its prognostic accuracy. NLR also demonstrated prognostic value both independently and as component of NLR-monocyte-age-based model, highlighting its potential as a robust tool for risk stratification.
dc.identifier.doi10.1182/bloodadvances.2025017896
dc.identifier.endpage1259
dc.identifier.issn2473-9529
dc.identifier.issn2473-9537
dc.identifier.issue4
dc.identifier.scopus2-s2.0-105029619963
dc.identifier.scopusqualityQ1
dc.identifier.startpage1250
dc.identifier.urihttps://doi.org/10.1182/bloodadvances.2025017896
dc.identifier.urihttps://hdl.handle.net/11486/8475
dc.identifier.volume10
dc.identifier.wosWOS:001698120000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBlood Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subject#BAŞV!
dc.titleA practical tool for predicting outcomes in essential thrombocythemia: Triple A risk model and beyond
dc.typeArticle

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