Current perspectives on the role of oxytocin receptor (OXTR) gene variants in panic disorder: associations with disease liability and separation anxiety

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dc.contributor.authorYegin, Zeynep
dc.contributor.authorSarisoy, Gokhan
dc.contributor.authorUzun, Ahmet
dc.contributor.authorAltinisik, Yasin
dc.date.accessioned2026-04-25T14:20:31Z
dc.date.available2026-04-25T14:20:31Z
dc.date.issued2026
dc.departmentSinop Üniversitesi
dc.description.abstractIntroduction: Oxytocin receptor (OXTR) gene variations are associated with empathy, trust, emotional stability, stress reactivity, social bonding and attachment behaviors. We aimed to explore the impact of three OXTR gene variations (rs53576, rs237902, rs2254298) in susceptibility to panic disorder (PD). We also investigated the possible effects of these variants on separation anxiety scale scores in patients, with a comprehensive approach covering environmental adversity effects. Material and methods: The hypothesis was studied in PD patients and healthy controls with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. By applying the Separation Anxiety Symptom Inventory (SASI) and the Adult Separation Anxiety Questionnaire (ASA), the relationships between the OXTR gene variants and these scales were also evaluated comprehensively. Results: A statistically significant association was found for OXTR rs237902; presence of the A allele was associated with a 1.585-fold increase in probability of PD. Moreover, all of the analyzed OXTR variants were found to be associated with childhood and adult separation anxiety in the patients in the combined analyses of various demographic and clinical data; striking associations of AA genotype with SASI and ASA scores were observed in these models. Conclusions: The study supports the involvement of oxytocinergic gene variants in PD. It also represents one of the most comprehensive models examining gene-environment (G & times; E) interactions in this context.
dc.description.sponsorshipSinop Universi-ty Scientific Research Projects Coordination Unit [SHMYO-1901-21-002]
dc.description.sponsorshipFunding This work was supported by Sinop Universi-ty Scientific Research Projects Coordination Unit (project number: SHMYO-1901-21-002) .
dc.identifier.doi10.5114/aoms/200392
dc.identifier.endpage514
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105034759992
dc.identifier.scopusqualityQ1
dc.identifier.startpage506
dc.identifier.urihttps://doi.org/10.5114/aoms/200392
dc.identifier.urihttps://hdl.handle.net/11486/8623
dc.identifier.volume22
dc.identifier.wosWOS:001728076100042
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subjectpanic disorder
dc.subjectoxytocin receptor gene
dc.subjectOXTR rs53576
dc.subjectOXTR rs237902
dc.subjectOXTR rs2 254298
dc.subjectseparation anxiety
dc.titleCurrent perspectives on the role of oxytocin receptor (OXTR) gene variants in panic disorder: associations with disease liability and separation anxiety
dc.typeArticle

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