New metal complexes with diclofenac containing 2-pyridineethanol or 2-pyridinepropanol: synthesis, structural, spectroscopic, thermal properties, catechol oxidase and carbonic anhydrase activities

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dc.authoridDilek, Esra/0000-0002-3629-5168
dc.contributor.authorCaglar, Sema
dc.contributor.authorDilek, Esra
dc.contributor.authorCaglar, Bulent
dc.contributor.authorAdiguzel, Ekrem
dc.contributor.authorTemel, Ersin
dc.contributor.authorBuyukgungor, Orhan
dc.contributor.authorTabak, Ahmet
dc.date.accessioned2025-03-23T19:35:26Z
dc.date.available2025-03-23T19:35:26Z
dc.date.issued2016
dc.departmentSinop Üniversitesi
dc.description.abstractFour new neutral diclofenac-based complexes, [Co(dicl)2(2-pyet)2] 1, [Ni(dicl)2(2-pyet)2] 2, [Cu2(dicl)2(2-pyet)2] 3, and [Cu2(dicl)2(2-pypr)2] 4 have been synthesized and characterized by elemental analysis, FT-IR, thermal analysis. Complexes 1, 3, and 4 have also been characterized by X-ray single-crystal structural analysis. The compounds of Co(II) and Ni(II) have octahedral geometry with two diclofenac and two 2-pyridineethanol ligands in the coordination sphere. The compounds of Cu(II) have square-pyramidal geometry and Cu(II) ions are linked via oxygens to the bridging 2-pyridineethanol or 2-pyridinepropanol ligands. The values acquired by FT-IR are in agreement with the single XRD data. Studies on the thermal properties are reported and the complexes are stable to 196, 216, 215, and 201 degrees C in air, respectively. Two dinuclear Cu(II) complexes have demonstrated catalytic activity on oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butylquinone showing saturation kinetics at high substrate concentrations. The diclofenac complexes are investigated as inhibitors of the human cytosolic isoforms hCA I and II. The complexes are good as hCA I inhibitors (Kis of 1.52-55.06M) but only moderately efficient as hCA II inhibitors (Kis of 0.23-5.61M). [GRAPHICS] .
dc.description.sponsorshipResearch Foundation of Erzincan University [110205]
dc.description.sponsorshipThis work was supported by the Research Foundation of Erzincan University [grant number 110205].
dc.identifier.doi10.1080/00958972.2016.1227802
dc.identifier.endpage3335
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue22
dc.identifier.scopus2-s2.0-84991069458
dc.identifier.scopusqualityQ3
dc.identifier.startpage3321
dc.identifier.urihttps://doi.org/10.1080/00958972.2016.1227802
dc.identifier.urihttps://hdl.handle.net/11486/5868
dc.identifier.volume69
dc.identifier.wosWOS:000386021200003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectDiclofenac
dc.subjectcrystal structure
dc.subjectFTIR
dc.subjectcatechol oxidation
dc.subjectcarbonic anhydrases
dc.titleNew metal complexes with diclofenac containing 2-pyridineethanol or 2-pyridinepropanol: synthesis, structural, spectroscopic, thermal properties, catechol oxidase and carbonic anhydrase activities
dc.typeArticle

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