Thymoquinone Down-regulates VEGFA and Up-regulates FLT1 Transcriptional Levels in Human Breast Cancer Cells

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dc.contributor.authorYegin, Z.
dc.contributor.authorDuran, T.
dc.contributor.authorYildirim, I. H.
dc.date.accessioned2025-03-23T19:26:36Z
dc.date.available2025-03-23T19:26:36Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractAngiogenesis is important for cancer progression index and angiogenesis factors related to tumorogenesis deserve to be investigated in detail. The use of minimally toxic phytochemical compounds as the new generation anticancer agents is an appreciated approach to manage angiogenesis factors. The purpose of this study was to investigate the potential effects of thymoquinone (TQ), the major constituent of the black seed, on the expression levels of VEGFA and its receptor FLT1 in human estrogen receptor-positive breast adenocarcinoma (MCF-7) cells. The researchers provide evidence that TQ down-regulated VEGFA and up-regulated FLT1 transcriptional levels in human breast cancer cells compared to HEK293 cells. To the best of the researchers' knowledge, this is the first study determining the effect of TQ in VEGFA and its receptor FLT1 in MCF-cells and more comprehensive investigations are highly recommended.
dc.identifier.doi10.31901/24566330.2020/20.01.746
dc.identifier.endpage24
dc.identifier.issn0972-3757
dc.identifier.issn2456-6330
dc.identifier.issue1
dc.identifier.scopusqualityN/A
dc.identifier.startpage19
dc.identifier.urihttps://doi.org/10.31901/24566330.2020/20.01.746
dc.identifier.urihttps://hdl.handle.net/11486/4735
dc.identifier.volume20
dc.identifier.wosWOS:000525344900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKamla-Raj Enterprises
dc.relation.ispartofInternational Journal of Human Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectAngiogenesis
dc.subjectBreast Tumor
dc.subjectMCF-7 Cells
dc.subjectThymoquinone
dc.subjectTranscription
dc.titleThymoquinone Down-regulates VEGFA and Up-regulates FLT1 Transcriptional Levels in Human Breast Cancer Cells
dc.typeArticle

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