The Effect of N-Acetylcysteine on the Neurofilament and Nerve Growth Factor Expression after Gentamicin Induced Cochlear Damage

Basit Öğe Kaydı
dc.contributor.authorSarsmaz, Hayrunnisa Yesil
dc.contributor.authorGurgen, Seren Gulsen
dc.contributor.authorSomdas, Mehmet Akif
dc.date.accessioned2025-03-23T19:30:32Z
dc.date.available2025-03-23T19:30:32Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractObjective: To investigate of the effectiveness of N-acetylcysteine (NAC) in preventing cochlear damage due to gentamicin by the means of expression of neuronal factors Metods: In our study, 36 female Spraguea Dawley rats were used. They were divided into 3 groups such as (saline), Gentamicin + Serum physiological (saline) and Gentamicin + NAC. After 15 days, the rats were sacrificed. Cochleae were removed and examined histopathologically. The immunoreactivity of neurofilament and neuronal growth factor primary antibodies was examined in the tissues taken. Results: Neuroflament immunoreactivity was quite significant in afferent and efferent nerve bundles in the saline group and Gentamicin + NAC group, whereas it was weak in the Gentamicin + serum physiological group. Also neuronal growth factor immunoreactivity was moderate in afferent and efferent nerve bundles in the saline group and Gentamicin + NAC group, it was negative at vestibular ganglia, and weak in afferent and efferent nerve fiber bundles in the Gentamicin + serum physiological group. Conclusion: It was shown immunohistochemically that ototoxicity caused by gentamicin was significantly reduced when the NAC combination was applied.
dc.identifier.doi10.12996/gmj.2022.54
dc.identifier.endpage237
dc.identifier.issn2147-2092
dc.identifier.issue3
dc.identifier.scopusqualityQ4
dc.identifier.startpage232
dc.identifier.urihttps://doi.org/10.12996/gmj.2022.54
dc.identifier.urihttps://hdl.handle.net/11486/5099
dc.identifier.volume33
dc.identifier.wosWOS:000823151400006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotr
dc.publisherGazi Univ, Fac Med
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectGentamicin
dc.subjectDrug Induced Ototoxicity
dc.subjectN-acetylcysteine
dc.subjectCochlea
dc.subjectNerve growth factor
dc.subjectNeurofilament protein
dc.titleThe Effect of N-Acetylcysteine on the Neurofilament and Nerve Growth Factor Expression after Gentamicin Induced Cochlear Damage
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu