Microwave-Assisted Synthesis of Tetrahydropyrimidines via Multicomponent Reactions and Evaluation of Biological Activities

Basit Öğe Kaydı
dc.contributor.authorAkbas, Esvet
dc.contributor.authorBerber, Ismet
dc.contributor.authorAkyazi, Inci
dc.contributor.authorAnil, Baris
dc.contributor.authorYildiz, Ela
dc.date.accessioned2025-03-23T19:27:14Z
dc.date.available2025-03-23T19:27:14Z
dc.date.issued2011
dc.departmentSinop Üniversitesi
dc.description.abstractVarious pyrimidine derivatives (1a-c) were synthesized using the Biginelli three component cyclocondensation reactions of a beta-diketone, arylaldehyde, and thiourea, under microwave irradiation and conventional conditions. The acetylation of compound 1a gave 3-acetyl thioxopyrimidin 2. Also, thiazolopyrimidine (3) and (4) derivatives were obtained by a simple one-pot condensation reaction of starting compounds 1a, and 1b with 2-bromopropionic acid. The prepared compounds were screened for their antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi using micro dilution procedure. The results of the study showed that the compound 4 was effective and selective for antimicrobial activity against the tested bacteria and fungi. Thus, we suggested that the compound 4 might be a new potential antimicrobial substance for bacteria and fungi.
dc.identifier.doi10.2174/157017811799304287
dc.identifier.endpage667
dc.identifier.issn1570-1786
dc.identifier.issn1875-6255
dc.identifier.issue9
dc.identifier.scopusqualityQ4
dc.identifier.startpage663
dc.identifier.urihttps://doi.org/10.2174/157017811799304287
dc.identifier.urihttps://hdl.handle.net/11486/4871
dc.identifier.volume8
dc.identifier.wosWOS:000299570700012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofLetters in Organic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectAntimicrobial substances
dc.subjectmicrowave-assisted
dc.subjectmulticomponent reactions
dc.titleMicrowave-Assisted Synthesis of Tetrahydropyrimidines via Multicomponent Reactions and Evaluation of Biological Activities
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu