Antiapoptotic and proliferative effect of bone marrow-derived mesenchymal stem cells on experimental Asherman model

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dc.contributor.authorOzturk, Samil
dc.contributor.authorSonmez, Pinar Kilicaslan
dc.contributor.authorOzdemir, Ilhan
dc.contributor.authorTopdagi, Yunus Emre
dc.contributor.authorTuglu, Mehmet Ibrahim
dc.date.accessioned2025-03-23T19:27:38Z
dc.date.available2025-03-23T19:27:38Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractPurpose: We investigated the effects of stem cell therapy as an alternative to surgical methods and medical treatments in endometrial injuries in Asherman syndrome (AS). Materials and Methods: In this study, AS model was created chemically in rats. The bone marrow-derived mesenchymal stem cells isolated from the tibia and femoral bone of male individuals of the same species (BMDSC) were given to female rats with asherman syndrome and the changes in the endometrium were evaluated by histopathological parameters. Asherman + medium, Asherman + niche, Asherman + BMDSCs, Asherman + BMDSCs + niche were formed in four groups. Results: It was observed that increased endometrial thickness, gland count and vascularization and decreased fibrous areas and apoptotic cell death with regeneration in epithelium and lamina propria in treatment groups. No histopathologic changes were observed in the right uterine horns, which were evaluated as control group.. Conclusion: BMDSCs and Niche applications can contribute to the clinic by reducing the formation of adhesion within the mechanisms causing infertility. These positive results are promising in terms of transporting Asherman studies to the clinic.It has been shown that BMDSCs and Niche may contribute to the clinic by treatment with adhesion molecules in mechanisms that cause infertility.
dc.identifier.doi10.17826/cumj.573200
dc.identifier.endpage446
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.scopusqualityN/A
dc.identifier.startpage434
dc.identifier.urihttps://doi.org/10.17826/cumj.573200
dc.identifier.urihttps://hdl.handle.net/11486/4955
dc.identifier.volume44
dc.identifier.wosWOS:000539685600054
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotr
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectMesenchymal stem cell
dc.subjectAsherman syndrome
dc.subjectapoptosis
dc.subjectinfertility
dc.subjecthistology
dc.titleAntiapoptotic and proliferative effect of bone marrow-derived mesenchymal stem cells on experimental Asherman model
dc.typeArticle

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