Multifunctional therapeutic hybrid nanocarriers for targeted and triggered drug delivery: recent trends and future prospects

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dc.contributor.authorKurtay, Gulbin
dc.contributor.authorYılmaz, Mehmet
dc.contributor.authorKuralay, Filiz
dc.contributor.authorDemirel, Gokcen B.
dc.date.accessioned2025-03-23T19:16:33Z
dc.date.available2025-03-23T19:16:33Z
dc.date.issued2017
dc.departmentSinop Üniversitesi
dc.description.abstractCancer is certainly among the most traumatic diseases with the addition of more than ten million new cases every year. The usage of chemotherapy agents is admissible as an effective treatment method despite of their well-known irreversible side effects to vital tissues and organs. In spite of the advancement in nanotechnology, which allows us to develop new generation nanocarriers, the human body is a very complex system and possesses many challenges such as biocompatibility, biodistribution, side effects, biological barriers, and so forth against drug delivery systems. In this regard, a perfectly designed nanocarrier should contain multifunctional properties to overcome these obstacles. Additionally, a smart nanocarrier system should deliver the drug to the specific place at the right dosage and time. Therefore, to develop this kind of smart therapeutic system, the desired properties such as imaging, diagnosis, and targeted delivery might be combined into a single system by fabrication of a hybrid nanocarrier. On this account, the hybrid nanocarriers have a promising potential to find application areas in the future of nanomedicine. In this chapter, we will discuss the new generation and promising hybrid nanocarriers based on noble metal, porous silica, polymer, and core–shell therapeutics, which exhibit active targeting, triggered release of cargo, and imaging capability for in vivo studies. © 2017 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/B978-0-323-46143-6.00015-4
dc.identifier.endpage493
dc.identifier.isbn978-032346143-6
dc.identifier.isbn978-032346149-8
dc.identifier.scopus2-s2.0-85124858977
dc.identifier.scopusqualityN/A
dc.identifier.startpage461
dc.identifier.urihttps://doi.org/10.1016/B978-0-323-46143-6.00015-4
dc.identifier.urihttps://hdl.handle.net/11486/4133
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofNanostructures for Drug Delivery
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250323
dc.subjectbioimaging
dc.subjectcancer treatment
dc.subjectcore–shell nanoparticles
dc.subjectdrug delivery
dc.subjectnoble metals
dc.subjectpolymeric nanoparticles
dc.subjectsilica nanoparticles
dc.subjecttheranostics
dc.subjecttherapeutics
dc.titleMultifunctional therapeutic hybrid nanocarriers for targeted and triggered drug delivery: recent trends and future prospects
dc.typeBook Part

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