Effectiveness of vitamin D3 in facilitating the therapeutic progression of healing diabetic foot ulcers

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dc.contributor.authorNouri, Fatemeh
dc.contributor.authorAghaei, Sara
dc.contributor.authorÖzbolat, Gülüzar
dc.contributor.authorDöğüş, Yusuf
dc.contributor.authorMirhamidi, Mahdi
dc.contributor.authorBarghani, Mahmoud Reza Rahimi
dc.contributor.authorDaemi, Amin
dc.date.accessioned2026-04-25T14:13:29Z
dc.date.available2026-04-25T14:13:29Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractBackground: Diabetes and its complications afflict a large portion of the population worldwide, and it is estimated that its prevalence in all age groups will increase from 2.8% in 2000 to 4.4% in 2030. Moreover, it is well known that vitamin D may cause rapid wound healing and exert anti-inflammatory effects. Objective: This study aimed to investigate the efficacy of vitamin D3 on the healing of chronic diabetic foot ulcers to improve the quality of life of patients with diabetes. The present research is conducted as a randomized controlled trial. Methods: Forty patients were randomly divided into an experimental group (vitamin D supplementation) and a control group (placebo) using a sampling method based on the inclusion criteria. The patients were evaluated for ulcer debridement every two weeks (0 (T0), 2 (T1), 4 (T2), 6 (T3), 8 (T4), 10 (T5), and 12 (T6)) after the intervention. The collected data were analyzed using SPSS-23 software. Results: The experimental group exhibited significantly decreased ulcer length (−1.6 ± 0.8 cm vs. −0.5 ± 1.4 cm, P = 0.005), ulcer width (−1.7 ± 1.2 cm vs. −0.9 ± 1.2 cm, P = 0.025), and ulcer depth (−0.6 ± 0.5 cmvs. −0.3 ± 0.4 cm, P = 0.025) after 12 weeks of intervention compared to those of the control group. These results reveal that vitamin D had a significant relationship with all stages of the wound-healing process (P < 0.01). Conclusions: In patients with chronic diabetic foot ulcers, the use of vitamin D supplementation can improve wound healing. Moreover, vitamin D had a significant relationship with all stages of the wound-healing process except re-epithelialization and angiogenesis. © 2025, Chulalongkorn University Printing House. All rights reserved.
dc.identifier.doi10.56808/2673-060X.5608
dc.identifier.endpage298
dc.identifier.issn2651-2343
dc.identifier.issue5
dc.identifier.scopus2-s2.0-105019307341
dc.identifier.scopusqualityQ4
dc.identifier.startpage291
dc.identifier.urihttps://doi.org/10.56808/2673-060X.5608
dc.identifier.urihttps://hdl.handle.net/11486/8107
dc.identifier.volume69
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherChulalongkorn University Printing House
dc.relation.ispartofChulalongkorn Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260420
dc.subjectMetabolic status
dc.subjectvitamin D
dc.subjectvitamin D supplementation
dc.subjectwound healing
dc.titleEffectiveness of vitamin D3 in facilitating the therapeutic progression of healing diabetic foot ulcers
dc.typeArticle

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