Sequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome

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dc.authoridVANIZOR KURAL, Birgul/0000-0003-0730-9660
dc.authoridBARLAK, YASAM/0000-0001-9174-6868
dc.authoridTURAN, IBRAHIM/0000-0003-3400-5494
dc.contributor.authorKural, Birgul Vanizor
dc.contributor.authorDeger, Orhan
dc.contributor.authorErem, Cihangir
dc.contributor.authorYucesan, Fulya Balaban
dc.contributor.authorBarlak, Yasam
dc.contributor.authorTuran, Ibrahim
dc.contributor.authorAliyazicioglu, Rezzan
dc.date.accessioned2025-03-23T19:25:36Z
dc.date.available2025-03-23T19:25:36Z
dc.date.issued2013
dc.departmentSinop Üniversitesi
dc.description.abstractObjective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator. Material and Methods: The study groups included 73 MetS (19 M/54 F) and 56 non-MetS (16 M/40 F). Sequence variation in exons 2, 4, 5 and 14 of the LPIN1 gene were investigated by DNA sequencing method. Results: c.696 G>C variant (p.S232S) in exon 5 was observed in only one women with MetS. But this variation is not important because of coding same amino acid. Conclusion: Any important sequence variant was not detected in exons 2, 4, 5 and 14 in the LPIN1 gene in MetS.
dc.description.sponsorshipKaradeniz Technical University Research Fund [2006.114.001.2, 2003.114.003.5, 2008.114.001.12]
dc.description.sponsorshipThe authors thank Karadeniz Technical University Research Fund (Project no: 2006.114.001.2, Project No: 2003.114.003.5 and Project No: 2008.114.001.12) for supplying financial support. In addition, thanks Arif HACIHASANOGLU, Ilgin HOSVER and Mihriban AYVAZ for their help in collecting of blood samples, and thanks Assoc. Prof. Ersan KALAY for technical support to analyze DNA sequences.
dc.identifier.doi10.5505/tjb.2013.41033
dc.identifier.endpage285
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage280
dc.identifier.urihttps://doi.org/10.5505/tjb.2013.41033
dc.identifier.urihttps://hdl.handle.net/11486/4520
dc.identifier.volume38
dc.identifier.wosWOS:000328162700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectmetabolic syndrome
dc.subjectLPIN1
dc.subjectlipin-1
dc.titleSequence Variant in the LPIN1 gene in Patients with Metabolic Syndrome
dc.typeArticle

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