Nörodejeneratif Hastaliklarda Umut Verici Bir Terapötik Hedef: Sestrin-2
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Esra DEMIRARSLAN
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Alzheimer, Parkinson, Huntington ve amyotrofik lateral skleroz dâhil olmak üzere nörodejeneratif hastaliklar günümüz dünyasinda giderek daha yaygin hale gelen, multifaktöriyel ve ilerleyici tipte hastaliklardir. Nörodejeneratif bozukluklarin yaygin etiyolojilerinin basinda yaslanma, oksidatif stres ve mitokondriyal disfonksiyon gelmektedir. Nörodejeneratif hastaliklarin tedavisinde kullanilan güncel ilaçlar hastanin yasam kalitesini iyilestirse de hastaligin gelisimini ve ilerlemesini yavaslatan veya önleyen bir tedavi henüz mevcut degildir. Bu ilaçlarin en büyük dezavantaji ise kronik kullanimlarinda ciddi yan etkilerle karsilasilmasidir. Bu kapsamda yeni terapötik hedeflere yönelik uzun vadede yan etki profili düsük yeni ajanlara ihtiyaç duyulmaktadir. Son zamanlarda gerçeklestirilen çalismalarda, stresle indüklenebilir bir metabolik protein olan Sestrin-2’nin reaktif oksijen türlerini baskiladigi, metabolizma ve inflamasyonu düzenledigi ve genotoksisite ve oksidatif stres, mitokondriyal disfonksiyon, endoplazmik retikulum stresi ve hipoksi dâhil olmak üzere çesitli zararli uyaranlara karsi hücresel koruma sagladigi gösterilmistir. Sestrin-2’nin düzenlenmesi ve sinyal mekanizmalarina iliskin çigir açan arastirmalarla, potansiyel rolü ve konak yanitindaki önemi konusundaki bilgilerimiz önemli derecede artmis olsa da Sestrin-2’nin nörodejeneratif hastaliklarda islevleri için daha fazla çalismaya ihtiyaç duyulmaktadir. Bu çalismada, nörodejeneratif hastaliklarda önemli bir terapötik hedef olma potansiyeline sahip Sestrin-2’ye dikkat çekmek amaciyla literatürdeki bilgiler detayli bir sekilde derlenmistir.
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis are the more common, multi-factorial, and progressive diseases in today’s world. The most common etiology of neurodegenerative disorders is aging, oxidative stress, and mitochondrial dysfunction. Modern medicines for the treatment of neurodegenerative diseases improve the patient’s quality of life, but no treatment slows down or prevents the development and progression of the disease. The greatest disadvantage of these drugs is that they cause serious side effects in their chronic use. New agents with low side effect profiles in the long term are needed for new therapeutic targets. Recent studies have shown that Sestrin-2, a stress-inducible metabolic protein, suppresses reactive oxygen species, regulates metabolism and inflammation, and provides cellular protection against various harmful stimuli including genotoxicity and oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and hypoxia. With groundbreaking research into the regulation and signaling mechanisms of sestrin-2, although our knowledge of its potential role and its importance to host response has increased considerably, its function in neurodegenerative diseases remains unclear. The present study compiled in detail the information in the literature to draw attention to sestrin-2, which has the potential to be a major therapeutic target in neurodegenerative diseases.
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis are the more common, multi-factorial, and progressive diseases in today’s world. The most common etiology of neurodegenerative disorders is aging, oxidative stress, and mitochondrial dysfunction. Modern medicines for the treatment of neurodegenerative diseases improve the patient’s quality of life, but no treatment slows down or prevents the development and progression of the disease. The greatest disadvantage of these drugs is that they cause serious side effects in their chronic use. New agents with low side effect profiles in the long term are needed for new therapeutic targets. Recent studies have shown that Sestrin-2, a stress-inducible metabolic protein, suppresses reactive oxygen species, regulates metabolism and inflammation, and provides cellular protection against various harmful stimuli including genotoxicity and oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and hypoxia. With groundbreaking research into the regulation and signaling mechanisms of sestrin-2, although our knowledge of its potential role and its importance to host response has increased considerably, its function in neurodegenerative diseases remains unclear. The present study compiled in detail the information in the literature to draw attention to sestrin-2, which has the potential to be a major therapeutic target in neurodegenerative diseases.
Açıklama
Anahtar Kelimeler
Nörodejeneratif Hastaliklar, Oksidatif Stres, Alzheimer Hastaligi
Kaynak
Saglik Akademisi Kastamonu
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
2
