Effect of Resveratrol and Quercetin on Intestinal Ischemia Reperfusion Injury in Rats

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dc.contributor.authorYağmur, Işıl
dc.contributor.authorDindar, Selen
dc.contributor.authorTural, Rabia
dc.contributor.authorYaylalı, Aslı
dc.contributor.authorYoldas, Atila
dc.contributor.authorTolun, Fatma Inanc
dc.contributor.authorDaglı, Hasan
dc.date.accessioned2025-03-23T19:09:04Z
dc.date.available2025-03-23T19:09:04Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractAim: Intestinal ischemia reperfusion (I/R) injury is an emergency condition with a high mortality rate and early diagnosis is very difficult. In this study, we aimed to examine the biochemical and histopathological effects of resveratrol and quercetin on intestinal I/R injury model. Material and Method: In our study, 56 male Sprague-Dawley rats weighing 250-300 g were randomly divided into 7 groups consisting of 8 rats. Groups were control group (group 1), saline group (group 2), ethanol group (group 3), resveratrol group (group 4) (30mg/kg), quercetin group (group 5) (30mg/kg), resveratrol+quercetin group A (group 6) (15 mg/kg+15 mg/kg), resveratrol+quercetin group B (group 7) (30 mg/kg+30 mg/kg). At the end of the experiment rats intestinal tissues were divided into 2 parts for biochemical and histopathological examination. Total oxidant level (TOS), total antioxidant level (TAS), total thiol [(-SH)+(-S-S-)] (TT), native thiol [-SH] (NT), and protein content levels were measured spectrophotometrically, oxidative stress index (OSI) and disulfide [-S-S-] levels were calculated. Results: A statistically significant difference was found between the groups in terms of TOS, OSI, TT, NT and disulfide levels (p
dc.identifier.doi10.36516/jocass.1303016
dc.identifier.endpage472
dc.identifier.issn2667-498X
dc.identifier.issue3
dc.identifier.startpage467
dc.identifier.trdizinid1222206
dc.identifier.urihttps://doi.org/10.36516/jocass.1303016
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1222206
dc.identifier.urihttps://hdl.handle.net/11486/3266
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofÇukurova Anestezi ve Cerrahi Bilimler Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250323
dc.subjectBiyoloji
dc.subjectKimya
dc.subjectAnalitik
dc.subjectKimya
dc.subjectTıbbi
dc.subjectGastroenteroloji ve Hepatoloji
dc.titleEffect of Resveratrol and Quercetin on Intestinal Ischemia Reperfusion Injury in Rats
dc.typeArticle

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