Cytotoxicity and Anti-Angiogenic Potential of a Macro Alga, Ulva rigida C. Agardh (Green Alga) from Izmir Bay (Turkey)

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dc.contributor.authorGüler, Cem
dc.contributor.authorGüner, Adem
dc.contributor.authorYavaşoğlu, N. Ülkü Karabay
dc.date.accessioned2025-03-23T19:16:40Z
dc.date.available2025-03-23T19:16:40Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractAbstract: Marine based organisms and their bioactive compounds are very attractive in terms of biomedical area. Due to marine ecosystem have harsh environment conditions; marine algae synthesize various bioactive compounds to survive. Genus Ulva (green macro algae) or sea lettuce species are the most abundant representatives abound in coastal waters and have various bioactive compounds. Therefore, Ulva sp. is extensively researched in especially cancer treatment. In this study, the ethanol extract of Ulva rigida C. Agardh collected from Izmir Bay was investigated by MTT, LDH, TAC, TOS and HET-CAM assays to determine its anticancer potential. The extract of U. rigida showed significant cytotoxic effect on human cervix adenocarcinoma (HeLa) cells (IC50 value is 21 ± 4.84 mg/L). The extract had a moderate anti-angiogenic activity (Score value is 0.98 ± 0.3 at 50 μM concentration). Our results showed that U. rigida has a good potential cervical cancer therapy agent. © Pleiades Publishing, Inc. 2023.
dc.identifier.doi10.1134/S1062359022603299
dc.identifier.endpageS269
dc.identifier.issn1062-3590
dc.identifier.issueSuppl 3
dc.identifier.scopus2-s2.0-85182645270
dc.identifier.scopusqualityQ4
dc.identifier.startpageS261
dc.identifier.urihttps://doi.org/10.1134/S1062359022603299
dc.identifier.urihttps://hdl.handle.net/11486/4175
dc.identifier.volume50
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing
dc.relation.ispartofBiology Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250323
dc.subjectanti-angiogenesis
dc.subjectanticancer
dc.subjectgreen algae
dc.subjectmacro algae
dc.subjectUlva rigida
dc.titleCytotoxicity and Anti-Angiogenic Potential of a Macro Alga, Ulva rigida C. Agardh (Green Alga) from Izmir Bay (Turkey)
dc.typeArticle

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