Antioxidant activities of inula viscosa extract and curcumin on U87 cells induced by beta-amyloid

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dc.authoridAlizade, Ares/0000-0003-0334-8152
dc.contributor.authorAlizade, Ares
dc.contributor.authorOzbolat, Guluzar
dc.date.accessioned2025-03-23T19:27:37Z
dc.date.available2025-03-23T19:27:37Z
dc.date.issued2021
dc.departmentSinop Üniversitesi
dc.description.abstractPurpose: The aim of this study was to investigate the effects of Inula viscosa extract and Curcumin on the U87 (human astrocytoma cell line) treated with amyloid-beta (A beta), which is the Alzheimer's disease (AD) model cell line. Materials and Methods: Firstly, the cytotoxic potential of inula and curcumin was investigated in the U87 cells by the colorimetric MF1 (3-4,5-dimethyl-thiazolyl-2,5-diphenyltetrazolium bromide) assay. Then, the amount of Total Glutathione, Malondialdehyde (MDA), Glutathione reductase (GR) activities were investigated. ELISA test was used to examine the expression and activity of cleaved Bax and Bcl-2 proteins in the Inula viscosa and Curcumin treated U87 cell lines. Results: Inula viscosa and Curcumin treatment reduced cell death caused by amyloid-B in cells. It also reduced oxidative stress caused by amyloid-B, while reducing the activation of the proapoptotic protein Bax, and Bcl-2. Conclusion: Our results suggest that inula viscosa may represent a new approach in the treatment of Alzheimer's.
dc.description.sponsorshipMustafa Kemal University Research Projects Unit [17.M.003]
dc.description.sponsorshipThis study was funded by Mustafa Kemal University Research Projects Unit (Project No.: 17.M.003).
dc.identifier.doi10.17826/cumj.854213
dc.identifier.endpage588
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2
dc.identifier.scopusqualityN/A
dc.identifier.startpage583
dc.identifier.urihttps://doi.org/10.17826/cumj.854213
dc.identifier.urihttps://hdl.handle.net/11486/4952
dc.identifier.volume46
dc.identifier.wosWOS:000694865200022
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectInula viscosa
dc.subjectcurcumin
dc.subjectAlzheimer
dc.subjectU87
dc.subjectBax
dc.subjectBcl-2
dc.titleAntioxidant activities of inula viscosa extract and curcumin on U87 cells induced by beta-amyloid
dc.typeArticle

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