The evaluation of ENA-78 and fibrinogen levels for the differential diagnosis of familial Mediterranean fever and acute appendicitis

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dc.authoridaktimur, recep/0000-0001-8781-9075
dc.authoridGuzel, Murat/0000-0003-0276-4576
dc.contributor.authorGuzel, Murat
dc.contributor.authorAktimur, Recep
dc.contributor.authorYildirim, Kadir
dc.contributor.authorAktimur, Sude Hatun
dc.contributor.authorTaskin, Mehmet Hakan
dc.contributor.authorDemir, Mehmet Cihat
dc.contributor.authorDemirag, Mehmet Derya
dc.date.accessioned2025-03-23T19:30:15Z
dc.date.available2025-03-23T19:30:15Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractBackground: Familial Mediterranean fever (FMF) is a disorder mainly present in the Mediterranean region, characterized by abdominal attacks that mimic acute peritonitis. Therefore, FMF might be confused with other conditions presenting with acute abdominal pain, particularly acute appendicitis (AA). We aimed to evaluate whether epithelial- derived neutrophil-activating peptide-78 (ENA-78) and fibrinogen levels and white blood cell (WBC) counts could be used as potential markers in the differential diagnosis of acute FMF attacks and AA. Methods: The study involved three groups: patients with AA who underwent surgery (group 1, n = 30), patients with FMF attacks (group 2, n = 30), and patients with FMF who were attack-free (n = 30, controls), which included patients who were diagnosed as having FMF previously Results: Significant differences were detected in the ENA-78 and fibrinogen levels between group 1 and group 2. No significant difference was found in the WBC count between group 1 and group 2. It was concluded that the WBC count was more sensitive (66%) for group 1, and fibrinogen showed higher sensitivity (86%) and specificity (96%) for group 2 compared with the other parameters. Conclusions: We suggest that AA can be distinguished in patients with signs of peritonitis who were diagnosed as having FMF previously with the use of ENA-78 and fibrinogen levels; fibrinogen and ENA-78 might be helpful in discriminating between FMF attacks and AA.
dc.identifier.doi10.1515/labmed-2018-0146
dc.identifier.endpage147
dc.identifier.issn2567-9430
dc.identifier.issn2567-9449
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.1515/labmed-2018-0146
dc.identifier.urihttps://hdl.handle.net/11486/5054
dc.identifier.volume43
dc.identifier.wosWOS:000471291400003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofJournal of Laboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectappendicitis
dc.subjectepithelial-derived neutrophil-activating peptide-78 (ENA-78)
dc.subjectfamilial Mediterranean fever
dc.subjectfibrinogen
dc.subjectwhite blood cell
dc.titleThe evaluation of ENA-78 and fibrinogen levels for the differential diagnosis of familial Mediterranean fever and acute appendicitis
dc.typeArticle

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