Effect of Cross-Sex Hormone Therapy on Hematological Parameters in Transmen: A 1-Year Follow-Up Study

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dc.authoridElbasan, Onur/0000-0001-8580-9471
dc.contributor.authorElbasan, Onur
dc.contributor.authorUstay, Ozlem
dc.date.accessioned2025-03-23T19:25:41Z
dc.date.available2025-03-23T19:25:41Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractObjective: Testosterone is the primary cross-sex hormone therapy (CSHT) for the female-to-male (transmen) transition. However, there is a growing concern about the safety and long-term results of CSHT, including erythrocytosis and inflammation. We aimed to investigate the effects of testosterone therapy on hematological parameters and high-sensitive C-reactive protein (hsCRP) in transmen with a 1-year follow-up. Methods: This was a single-center prospective study in 45 hormone-naive transmen and 28 age-and body mass index (BMI)-matched ciswomen. Ciswomen were compared with hormone-naive transmen. Testosterone ester preparation (250 mg) was prescribed to all transmen every 21 days. The transmen were evaluated before treatment and 6 and 12 months following CSHT. Sex steroids, complete blood counts, and hsCRP were analyzed. Results: At initial assessment before CSHT, the transmen had higher total testosterone (P = .002), white blood cell count (P = .013), and neutrophil count (P = .015) than the ciswomen. The exogenous testosterone administration to transmen was associated with a significant increase in hematocrit (P < .001) and hsCRP (P = .002) at 12 months. Conclusion: Testosterone administration to transmen was associated with a significant increase in hematocrit and hsCRP at 12 months. These parameters should be regularly monitored in line with current guidelines.
dc.identifier.doi10.5152/erp.2023.23256
dc.identifier.endpage226
dc.identifier.issn2822-6135
dc.identifier.issue4
dc.identifier.scopusqualityQ4
dc.identifier.startpage221
dc.identifier.urihttps://doi.org/10.5152/erp.2023.23256
dc.identifier.urihttps://hdl.handle.net/11486/4539
dc.identifier.volume27
dc.identifier.wosWOS:001097937500007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherAves
dc.relation.ispartofEndocrinology Research and Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectTransmen
dc.subjectciswomen
dc.subjectcross-sex hormone therapy
dc.subjecttestosterone
dc.subjecthematological parameters
dc.subjecthematocrit
dc.titleEffect of Cross-Sex Hormone Therapy on Hematological Parameters in Transmen: A 1-Year Follow-Up Study
dc.typeArticle

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