Protective effect of Asphodelus aestivus Brot. on bladder injury due to ischemia-reperfusion: Biochemical and histopathological Study

Basit Öğe Kaydı
dc.contributor.authorKopar, Hatice
dc.contributor.authorYagmur, Isil
dc.contributor.authorKurutas, Ergul Belge
dc.contributor.authorTural, Rabia
dc.date.accessioned2026-04-25T14:20:35Z
dc.date.available2026-04-25T14:20:35Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractSevere oxidative stress caused by reperfusion after ischemia in the bladder causes serious functional and structural damage. New molecules with antioxidant effects are needed to protect against this damage. In our study, we aimed to investigate the effect of Asphodelus aestivus on the oxidant-antioxidant system in bladder ischemia/reperfusion (I/R) injury induced in rats biochemically and histopathologically. In our study, 24 three-month-old male Wistar-Albino rats weighing 250-300 g were randomly divided into 3 groups of 8 rats each: sham group (I/R+serum physiological, 1mL) (group 1), I/R group (group 2), I/R+A. aestivus group (50 mg/kg/day) (treatment group, group 3). At the end of the experiment, all rats were sacrificed and their bladder tissues were taken and divided into 2 parts for biochemical and histopathological examination. Protein amount, malondialdehyde (MDA) levels and superoxide dismutase (SOD) and catalase (CAT) enzyme activity levels were measured spectrophotometrically, and histopathological examination was performed under a light microscope. MDA levels were significantly higher and CAT activity was significantly lower in the I/R group compared to the sham and treatment groups (P<0.05). In histopathological examination, it was determined that there was a significant regression and/or decrease in the findings caused by I/R injury in the group treated with A. aestivus. A. aestivus has a protective effect in reducing oxidative stress in bladder I/R injury.
dc.description.sponsorshipKahramanmarascedil; Suetcue Idot;mam University Scientific Research Projects Management Unit (BAP) [2019/2-6 YLS]
dc.description.sponsorshipAcknowledgments This study was supported by Kahramanmara & scedil; Sutcu & Idot; mam University Scientific Research Projects Management Unit (BAP, Project number: 2019/2-6 YLS) . Thanks to Sevgi Bakar & imath; & scedil; and Mehmet Fatih Yuzba & scedil; & imath; o & gbreve; lu for their assistance in the study.
dc.identifier.doi10.56042/ijeb.v63i10.12669
dc.identifier.endpage862
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue10
dc.identifier.scopusqualityN/A
dc.identifier.startpage857
dc.identifier.urihttps://doi.org/10.56042/ijeb.v63i10.12669
dc.identifier.urihttps://hdl.handle.net/11486/8640
dc.identifier.volume63
dc.identifier.wosWOS:001654855400007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNatl Inst Science Communication-Niscair
dc.relation.ispartofIndian Journal of Experimental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subjectAntioxidant
dc.subjectCatalase
dc.subjectMalondialdehyde
dc.subjectOxidative stress
dc.subjectSuperoxide dismutase
dc.titleProtective effect of Asphodelus aestivus Brot. on bladder injury due to ischemia-reperfusion: Biochemical and histopathological Study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu