Roles of p53 Codon 72 and miR-502-binding Site in the 3′-UTR of SET8 SNPs in Urinary Bladder Cancer Predisposition in Turkish Population

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dc.contributor.authorYegin, Z.
dc.contributor.authorOzen, F.
dc.contributor.authorKoc, H.
dc.contributor.authorUlus, I
dc.contributor.authorYildirim, A.
dc.contributor.authorBuyukalpelli, R.
dc.date.accessioned2025-03-23T19:26:36Z
dc.date.available2025-03-23T19:26:36Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractA case-control study was conducted to elucidate the possible roles of two SNPs (TP53 codon 72 and SET8 miR-502) that may affect each other in the same signaling pathway in bladder cancer susceptibility. Genotype distributions of 180 bladder cancer patients in comparison with 203 cancer-free controls were tested using PCR-RFLP method. For TP53, the researchers observed some protective effect of CC (Pro/Pro) genotype when compared with the heterozygous form (CG). For SET8 miR502, the researchers found no significant association in terms of variant alleles. These data suggest the association of TP53 codon 72 SNP, but not SET8 miR-502 with bladder cancer susceptibility in Turkish population. Further studies with larger sample sizes and different ethnicities are desirable to validate the researchers' findings.
dc.identifier.doi10.31901/24566330.2019/19.03.735
dc.identifier.endpage145
dc.identifier.issn0972-3757
dc.identifier.issue3
dc.identifier.scopusqualityN/A
dc.identifier.startpage138
dc.identifier.urihttps://doi.org/10.31901/24566330.2019/19.03.735
dc.identifier.urihttps://hdl.handle.net/11486/4737
dc.identifier.volume19
dc.identifier.wosWOS:000489124900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKamla-Raj Enterprises
dc.relation.ispartofInternational Journal of Human Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectBladder Cancer
dc.subjectGenetic Susceptibility
dc.subjectmicroRNA
dc.subjectp53
dc.subjectSET8
dc.titleRoles of p53 Codon 72 and miR-502-binding Site in the 3′-UTR of SET8 SNPs in Urinary Bladder Cancer Predisposition in Turkish Population
dc.typeArticle

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