Evaluation of Rheum ribes L. Protective Effect with G Protein-Coupled Estrogen Receptor-1 (GPER-1) Levels in Experimental Liver Ischemia-Reperfusion Model

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dc.contributor.authorYağmur, Işıl
dc.contributor.authorKurutas, Ergul Belge
dc.contributor.authorYuzbasioglu, Mehmet Fatih
dc.contributor.authorBakaris, Sevgi
dc.contributor.authorÇitil, Büşra
dc.contributor.authorDoğaner, Adem
dc.contributor.authorTural, Rabia
dc.date.accessioned2025-03-23T19:12:24Z
dc.date.available2025-03-23T19:12:24Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractObjective: To evaluate the relationship between the cell protective effects of Rheum ribes L. and G protein-coupled estrogen receptor-1 (GPER-1) levels in ischemia-reperfusion (I/R) injury. Material and Method: The 32 male Wistar-Albino rats we used in this study were randomly divided into 4 groups of 8 rats each; control group (group 1), sham group (group 2), I/R group (group 3), I/R+Rheum ribes L. group (group 4). While no procedure was applied to the control group, 30 minutes of ischemia followed by 30 minutes of reperfusion was applied to the rats in all other groups. GPER-1 levels in liver tissue were measured with an ELISA reader. Histopathological examination of the tissues was performed under light microscopy. Results: As a result of biochemical analysis; GPER-1 levels were statistically significantly decreased in the sham and I/R groups compared to control and I/R+Rheum ribes L. groups; in the I/R+Rheum ribes L. group compared to the control group (p <0.05). In the histopathological examination of the liver, necrosis and congestion observed in the Sham and I/R groups were significant when compared to the control group. While vacuolization was observed in a few experimental animals, there was a significant difference in the sham and I/R groups compared to the control group (p ˂0.05). I/R+Rheum ribes L. group showed improvement in histopathological criteria in terms of vacuolization and necrosis compared to the sham group and I/R groups, and the difference was significant. (p ˂0.05). Conclusion: Rheum ribes L. can protect hepatocytes both with its antioxidant effects and GPER-1 activation.
dc.identifier.endpage251
dc.identifier.issn1300-9818
dc.identifier.issn2147-124X
dc.identifier.issue4
dc.identifier.startpage245
dc.identifier.trdizinid1277394
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1277394
dc.identifier.urihttps://hdl.handle.net/11486/3823
dc.identifier.volume28
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofFırat Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250323
dc.subjectLiver
dc.subjectRheum ribes L.
dc.subjectGPER-1
dc.subjectIschemia Reperfusion Injury
dc.titleEvaluation of Rheum ribes L. Protective Effect with G Protein-Coupled Estrogen Receptor-1 (GPER-1) Levels in Experimental Liver Ischemia-Reperfusion Model
dc.typeArticle

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