Evaluation of CDH1 Promoter Methylation and HPV Infection Status in the Development of Parotid Pleomorphic Adenoma

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dc.authoridAvsar, cumhur/0000-0002-4095-0022
dc.contributor.authorOzen, F.
dc.contributor.authorYegin, Z.
dc.contributor.authorAcar, G. O.
dc.contributor.authorAvsar, C.
dc.contributor.authorZenginkinet, T.
dc.date.accessioned2025-03-23T19:26:36Z
dc.date.available2025-03-23T19:26:36Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractBoth benign and malignant salivary gland tumors are clinically heterogeneous and they display different histology. Researchers aimed to elucidate the potential roles of both CDH1 methylation and high-risk oncogenic human papilloma virus (HPV) types HPV16 and HPV18 in parotid pleomorphic adenoma. Genomic DNA samples extracted from fonnalin-fixed paraffin-embedded (FFPE) samples of parotid pleomorphic adenoma and control tissues were subjected to methylation specific PCR (MSP) for hypermethylation analyses. HPV infection presence was evaluated using both GP5+/GP6+ consensus primers and type-specific primers for IIPVI6 and HPVI8. Both CDH1 promoter hypermethylation and HPV16 infection partially seemed to be responsible in the occurrence of the tumors. According to the best of the researchers' knowledge, this is the first study investigating the possible roles of both CDH1 methylation and HPV involvement in parotid pleomorphic adenoma. Multicentered studies with larger sample cohorts could be highly beneficial to strengthen this study's results and thus draw a more precise conclusion
dc.identifier.doi10.31901/24566330.2020/20.01.745
dc.identifier.endpage18
dc.identifier.issn0972-3757
dc.identifier.issn2456-6330
dc.identifier.issue1
dc.identifier.scopusqualityN/A
dc.identifier.startpage11
dc.identifier.urihttps://doi.org/10.31901/24566330.2020/20.01.745
dc.identifier.urihttps://hdl.handle.net/11486/4736
dc.identifier.volume20
dc.identifier.wosWOS:000525344900002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKamla-Raj Enterprises
dc.relation.ispartofInternational Journal of Human Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectCDH1
dc.subjectHPV16
dc.subjectHPV18
dc.subjectHuman Papilloma Virus
dc.subjectHypermethylation
dc.subjectParotid Gland Tumor
dc.titleEvaluation of CDH1 Promoter Methylation and HPV Infection Status in the Development of Parotid Pleomorphic Adenoma
dc.typeArticle

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