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    Interaction of nonsteroidal anti-inflammatory drug naproxen sodium with DNA by electrochemical and spectroscopic methods
    (Hacettepe University Journal of the Faculty of Pharmacy, 2011) Yola, Mehmet Lütfi; Arıcı, Mürsel; Özaltın, Nuran
    Naproxen sodium (NAPS), the sodium salt of (S)-6-methoxy-a-methyl-2-naphtalenacetic acid (Figure 1) is a non-steroidal anti inflammatory drug, which is used in the treatment of severe pain and inflammation. Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase),
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    Investigation of interaction of simvastatin with human genomic DNA
    (Hacettepe University Journal of the Faculty of Pharmacy, 2012) Yola, Mehmet Lütfi; Özaltın, Nurhan
    [Abstract Not Available]
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    Square-wave voltammetric determination of ezetimibe
    (Revista De Chimie, 2011) Yola, Mehmet Lütfi; Özaltın, Nuran
    voltammetry (SWV) at a hanging mercury-drop electrode (HMDE) in electrolytes of different pH. Ezetimibe gave rise to a single voltammetric peak in the potential interval from -1290 to - 1322 mV depending on ezetimibe concentration within the entire pH range (4.0 – 10.0) in K2HPO4 – Na2B4O7 (25:25) (v/v) buffer. The well-defined peaks were observed at the frequency of 50 Hz, amplitude of 20 mV, potential increment of 3 mV. The developed method was validated according to the ICH guideline and found to be linear, sensitive, specific, precise, accurate, rugged and robust. Limit of detection (LOD) and limit of quantification (LOQ) were found 0.099 ?g mL-1 and 0.30 ?g mL-1 respectively. The linearity range of ezetimibe was 0.33 – 6.54 ?g mL-1 under the optimum conditions. The developed method was applied successfully for the determination of ezetimibe in tablet dosage form. Also electrochemical behaviours of ezetimibe were investigated. As a results of cyclic voltammetry (CV) and SWV experiments, the reduction mechanism included 2 electrons and 2 protons, and further more, reduction current of ezetimibe was diffusion controlled and the electrode reaction was found to be irreversible by using CV, chronoamperometry (CA) and choronocoulometry (CC) methods. Using these electrochemical techniques diffusion coefficient (D), rate constant for electron transfer (kf) and rate constant of following chemical reaction (k) relating to ezetimibe’s reduction reaction was calculated. It was found out that the reduction reaction occured according to EC mechanism and possible reduction mechanism was proposed.
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    Synthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5-Dihydro-1H-1,2,4-Triazol-5-One Derivatives
    (Archiv der Pharmazie-Chemistry in Life Sciences, 2013) Yüksek, Haydar; Akyıldırım, Onur; Yola, Mehmet Lütfi; Kol, Özlem Gürsoy; Çelebier, Mustafa; Kart, Didem
    A series of compounds derived from 4,5-dihydro-1H-1,2,4-triazol-5-one were synthesized and characterized by spectral data. The 12 new compounds were analyzed for their potential in vitro antioxidant activities by three different methods. Compound 4f showed the best activity for the iron binding. In addition, the compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide in non-aqueous solvents. The RP-HPLC capacity factors (k0) of the series were also determined on a C18 column, with methanol/water as the mobile phase. The correlation between log k0 with the percentage of methanol in the mobile phase was used for the determination of the log kw values for these compounds. The antimicrobial activities of these compounds were also screened against bacteria and yeast.