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    Biological Activity Studies of Some Synthesized Novel Furan and Pyran Derivatives
    (Gazi Univ, 2017) Sari, Esma; Aslan, Hakan; Dadi, Seyma; Oktemer, Atilla; Logoglu, Elif
    In this study, some novel furan and pyran derivatives were synthesized as mentioned in our previous report [1]. The novel furan and pyran derivatives were investigated for antibacterial activity against gram-positive/negative bacteria and fungus. The antibacterial and antifungal activities were determined by the disc diffusion method (DISC) and minimum inhibition concentration (MIC) against the tested bacteria and fungus. The inhibition zones were compared with those of reference discs which were studied in our previous work [2]. Reference discs used for control were as follows ketoconazole, ampicillin, tetracycline, penicillin, chloramphenicol, and gentamicin. From the results it could be said that some of the chemical compound can be used as a raw medicine sources.
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    Öğe
    Combined experimental and theoretical study of the novel ferrocene derivatives and examining the effect of E-Z stereoisomerism on their optical properties
    (Elsevier Science Bv, 2019) Aslan, Hakan; Kurtay, Gulbin; Korkmaz, Adem; Cetin, Adnan; Oktemer, Atilla
    Herein, we present the primary results on two valuable E-Z stereoisomers containing ferrocene scaffold [(E)-5,5-dimethy1-3-oxo-2-(2-phenyl-2-ferrocenyl-vinyl)cyclohex-1-en-1-yl acetate (E-FerCycAc) and its Z-stereoisomer (Z-FerCycAc)]. These compounds were both prepared from 1-phenylvinyl-ferrocene and 5,5-dimethyl-1,3-cyclohexanedione under catalysis of manganese(III) acetate according to the radical addition mechanism. The prominent spectroscopic data of the target stereoisomers were provided by FT-IR, LC-MS, (1) H NMR, (13) C NMR techniques, and their stereochemical identification was made primarily by NOESY analysis. The corresponding data (absorbance, transmittance and optical and transport energy gap) were collected from UV-vis studies. The optical properties of the glass slides coated with E-FerCycAc and Z-FerCycAc films were examined and consequently, the optical and transport energy band gap values of the E-FerCycAc were found significantly lower than Z-FerCycAc. The physicochemical and spectroscopic findings (HOMO-LUMO energies, bandgap values, UV-vis, FT-IR, (1) H, and (13) C NMR spectra) were also compared and supported with the acquired DFT calculations.
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    Öğe
    Synthesis, characterization, and investigations of antimicrobial activity of benzopyrans, benzofurans and spiro[4.5]decanes
    (Taylor & Francis Inc, 2018) Akpinar, Deniz E.; Ozgur (Nee Yakut), Mehtap; Aslan, Hakan; Alagoz, Oguzhan; Oktemer, Atilla; Dal, Hakan; Hokelek, Tuncer
    In this study, the radical cyclization reactions of cyclic 1,3-dicarbonyl compounds (1a-c) and a, b-unsaturated alcohols (2a-d) through Mn(OAc) 3 were performed. A series of biologically interesting dihydropyrans (3-5) and dihydrofurans (6-18) were synthesized as a result of these reactions. Spiro compounds (19-20) were obtained from the reactions of 1,3-dicarbonyl compounds and (E)-2,4-diphenyl-but-3-en2-ol (2e). The unique structure of compound 19 was also confirmed by X-ray crystallography. In addition, the antibacterial activities of synthesized compounds were screened against some bacteria. Their zone diameters showed better results than some known antibiotics.