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Öğe Correlation between Na/K ratio and electron densities in blood samples of breast cancer patients(Springer, 2018) Topdagi, Omer; Toker, Ozan; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Oz, Ersoy; Eyecioglu, Onder; Demir, MustafaThe main purpose of this study was to investigate the relationship between the electron densities and Na/K ratio which has important role in breast cancer disease. Determinations of sodium and potassium concentrations in blood samples performed with inductive coupled plasma-atomic emission spectrometry. Electron density values of blood samples were determined via ZXCOM. Statistical analyses were performed for electron densities and Na/K ratio including Kolmogorov-Smirnov normality tests, Spearman's rank correlation test and Mann-Whitney U test. It was found that the electron densities significantly differ between control and breast cancer groups. In addition, statistically significant positive correlation was found between the electron density and Na/K ratios in breast cancer group.Öğe Determination of Se, Cr, Mn, Zn, Co, Na, and K in Blood Samples of Breast Cancer Patients to Investigate Their Variation Using ICP-MS and ICP-OES(Atomic Spectroscopy Press Ltd, 2019) Toker, Ozan; Topdagi, Omer; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Oz, Ersoy; Eyecloglu, Onder; Karabul, YasarThe aim of this study was to investigate the concentration changes of Se, Mn, Cr, Zn, Co, Na and K in blood samples of breast cancer patients. Determination of the elements was performed using ICP-MS and ICP-OES instruments. Kolmogorov-Smirnov normality tests, Mann-Whitney U tests, Independent sample T tests and Spearman's rank correlation tests were performed for statistical comparisons. It was found that the concentrations of Na and K in breast cancer patients were higher than for healthy people. The Se, Mn, and Cr concentrations were found to be lower in patients with breat cancer. No increase/decrease in Zn concentrations between the two groups was observed. A positive correlation was found between the distribution of Zn and K elements. Independent sample t and Mann-Whitney U tests demonstrated that statistical differences were observed between patients having the diagnosis of breast cancer and healthy people in terms of the concentrations of Se, Cr and Na. The results presented in this study will contribute to the literature by showing the relationship between breast cancer and element concentrations.Öğe Determination of Trace Element Concentrations in Blood Samples and Their Correlation to Breast Cancer(Atomic Spectroscopy Press Ltd, 2020) Topdagi, Omer; Toker, Ozan; Bakirdere, Sezgin; Oz, Ersoy; Bursalioglu, Ertugrul Osman; Abuqbeitah, Mohammad; Demir, MustafaThe main purpose of this study was to investigate the possible differences in the concentrations of Al, Cu, Ca, Mg, Fe, Ni, and Pb in breast cancer patients and healthy control group. One blood sample each was collected from 40 adult female patients diagnosed with breast cancer and 40 healthy adult female individuals with no medical history of cancer. The concentrations of the elements Al, Cu, Fe, Ni, and Pb were determined by ICP-MS, while Ca and Mg were determined by ICP-OES. Statistical analysis was performed with the Kolmogorov-Smirnov normality test, the Mann-Whitney U test, and the Spearman's rank correlation test. It was observed that the concentrations of Cu and Mg in the breast cancer patients were significantly higher (p=0.000<0.05 and p=0.001<0.05, respectively) than for the healthy group, while the Al concentration was significantly lower (p=0.002<0.05) in the cancer patients. The Mg concentration in the control group and the patients was 33.60 +/- 4.51 and 38.10 +/- 9.69 mg/kg, respectively. The difference was statistically significant for Cu, Mg, and Al, whereas no difference was observed between the concentrations of Ca and Fe. Furthermore, a positive correlation was observed in breast cancer patients between the concentrations of (Al-Cu), (Al-Ca), (Fe-Mg), and (Cu-Ca).Öğe Effect of Cow Colostrum, Mare Milk, and Human Milk on the Viability of Lung Healthy and Cancer Cell Lines(Dubai Iranian Hosp, 2021) Bursalioglu, Ertugrul OsmanThis study investigated the effects of lyophilized mare milk, human milk, and cow colostrum on both human lung cancer cell line called A549, and healthy lung cell line called MRC5. Mare milk, human milk, and cow colostrum varieties were applied to 6 replicates in both cell lines with lyophilized milk concentrations ranging from 50 - 3200 ppm. The cell viability was monitored by optic microscopy and determined by the MTT test. ANOVA and Duncan's multiple range tests were used to analyze data. The results of this study indicated that the most effective milk type on reducing the A549 lung cancer cell line was human milk, followed by mare milk; however, cow colostrum showed little effect. It was observed that human milk and mare milk had anti-proliferative effects on lung cancer cell line at concentrations which were non-toxic to healthy lung cell line.Öğe Evaluation of gene interaction and similarity in 17 different cancer pathways(Marmara Univ, Fac Pharmacy, 2025) Bursalioglu, Ertugrul Osman; Kalay, Saban; Metin, SefaThis study investigates similarities and gene interactions in 17 different cancer types using Kyoto University's KEGG cancer pathways. Using Python software and the Google Colab platform, gene similarities and interactions within cancer pathways were calculated through Jaccard similarity indices and interaction analyses. The results reveal important genes and pathways shared between cancer types, providing insights into common molecular mechanisms underlying cancer development and progression. These findings may contribute to the identification of potential therapeutic targets by understanding the biological processes shared between cancers. In comparisons between different cancer types, gene similarities ranged between 43% and 47% and pathway similarities ranged between 25% and 46%. These results reveal that while some cancer types are genetically similar, they show differences in biochemical processes. In the gene interaction study among 17 different cancer pathways, the highest interaction rates were observed in colorectal cancer between entries '43-40' with ('activation'), in pancreatic cancer between entries '113-6' with ('activation'), and in hepatocellular carcinoma between entries '122-224' with ('activation'), showing nearly 100% interaction. On the other hand, the lowest interaction rates were found in colorectal cancer between entries '39-135' with ('missing interaction') and in melanoma between entries '95-106' with ('missing interaction'), showing 0% interaction.Öğe Evaluation of magnetic field assisted sun drying of food samples on drying time and mycotoxin production(Elsevier Sci Ltd, 2019) Nuroglu, Emine; Oz, Ersoy; Bakirdere, Sezgin; Bursalioglu, Ertugrul Osman; Kavanoz, Huseyin Birtan; Icelli, OrhanMycotoxins are a variety of metabolic products produced by fungi, which can cause various damages to other organisms. The aim of this study was to figure out the effect of new drying methods namely drying in oven under magnetic field and drying under the sun and magnetic field on the mycotoxin formation for some food samples. In this system, a fixed magnetic field of 300 mu T was used for the drying process. The amounts of moisture in the samples dried with the new developed methods were measured in hazelnut (Corylus L.), fig (Ficus calico L.), chili pepper (Capsicum annuum L.) and grape (Vitis vinifera L.) depending on time. Mycotoxin species within different foodstuffs were determined at trace levels by using LC-MS/MS device under the optimum conditions, and the results obtained from the samples dried with the new methods were compared with each other and results of food samples dried by traditional method. The results indicated that the new developed drying methods cause decrease in the drying periods, and the dried samples did not contain any mycotoxin. This study suggested new drying strategies to eliminate the mycotoxin formation. For the analysis of the results, different statistical tests were used. In order to determine which technique works faster in drying the samples, box plots were obtained using descriptive statistics. Mann Whitney tests were also applied to determine if there was a statistical difference between the drying methods.Öğe Gum Arabic Modulates Redox-Ionic Microenvironments via Rheology and Kinetics to Induce Selective Cytotoxicity in Colorectal Cancer Cells(Mdpi, 2026) Cebeci, Emre; Yuksel, Busra; Aliusta, Reyhan; Yilmaz, Sahin; Bursalioglu, Ertugrul Osman; Bozyel, Mustafa Eray; Gokce, Halise BetulBackground: Gum Arabic (GA) is a natural polysaccharide widely recognized for its antioxidant and anti-inflammatory properties; however, its functional behavior as a biopolymeric gel and the mechanisms underlying its selective effects on cancer-related redox microenvironments remain insufficiently characterized. It is imperative to note that the interaction between its physicochemical properties and its biological activity in colorectal cancer remains to be fully clarified. Methods: This study aimed to evaluate the antineoplastic potential of GA in human colorectal cancer (CRC) cell lines (HT-29 and HCT-116) compared to normal fibroblasts (MRC-5) using the MTS assay. Oxidative stress-related molecular responses were assessed by quantitative PCR analysis of GPX4, GSTA2, CAT, NFKB, and SOD1 expression. In parallel, extracellular concentrations of key metal ions (Fe2+, Zn2+, Mn2+, Mg2+, Cu2+, and Al3+) were quantified following GA exposure. To establish its functional gel characteristics, rheological measurements were performed to assess viscosity and shear-dependent behavior, and USP-compliant in vitro kinetic studies were conducted to evaluate time-dependent release properties. Results: GA induced dose-dependent cytotoxicity in HT-29 and HCT-116 colorectal cancer cells, while MRC-5 fibroblasts exhibited comparatively higher viability across the tested concentration range, indicating reduced sensitivity in normal cells. Rheological analysis revealed concentration- and ion-dependent viscoelastic behavior, identifying a 10% (w/w) GA formulation as optimal due to its balanced low-shear viscosity and controlled shear-thinning properties. Kinetic studies demonstrated a defined, diffusion-governed release profile under physiologically relevant conditions. At the molecular level, significant upregulation of GPX4 and GSTA2 was observed in both cancer cell lines, whereas NFKB expression increased selectively in HT-29 cells, with no notable changes in CAT or SOD1 expression. Additionally, GA treatment resulted in marked increases in Fe2+, Zn2+, and Mn2+ levels, indicating modulation of the redox-ionic microenvironment. Conclusions: These findings demonstrate that GA functions as a natural, ion-responsive biopolymeric system with defined rheological and kinetic properties, capable of selectively targeting colorectal cancer cells through coordinated genetic and ionic regulation of oxidative stress. Collectively, the results position GA as a promising functional gel-based platform for future redox-modulated therapeutic strategies in colorectal cancer.Öğe Investigation of in-situ changes in electrical behavior during one day with environmental effects of Spathiphyllum spp. and African violet (Saintpaulia ionantha)(Yildiz Technical University, 2019) Bursalioglu, Ertugrul OsmanPlants play an extremely important role in environmental cleanliness by reducing harmful gases in the atmosphere. Spathiphyllum spp. and African violet (Saintpaulia ionantha) plants are widely found in many countries of the world, decorative inside. Since these two plants are commercially propagated throughout the world, they have economic importance at the same time. Spathiphyllum spp. also has a separate prescription due to its ability to clean some air toxins in the interior. Simultaneously monitoring, the frequencies and electrical voltage values per hour were measured by using oscilloscope for during one day on the leaves of these plants. African violet plant decrease and Spathiphyllum spp. increase are showed in frequency values especially at night and in the near morning. The change in voltage values in the Spathiphyllum spp. plant was particularly reduced in the morning and the changes were clearer until the evening, and the voltage change in the African violet plant was at very low levels. © 2019 Yildiz Technical University. All rights reserved.Öğe INVESTIGATION OF THE EFFECT OF SOCIAL DISTANCE ON FREQUENCY AND VOLTAGE FLUCTUATIONS ON IDENTICAL OCIMUM BASILICUM L. PL ANTS INDOORS AND OUTDOORS FOR 24 HOURS USING A MIXED MODEL(Pakistan Botanical Soc, 2023) Bardak, Selahattin; Altinisik, Yasin; Bursalioglu, Ertugrul OsmanPlants play a vital role in environmental cleanliness by reducing harmful gases in the atmosphere. Genus Ocimum has a separate prescription due to its ability to clean air toxins in the interior. Ocimum has spread commercially all over the world due to its economic importance. Frequency and electrical voltage were measured on the leaves of two identical Ocimum basilicum L. , plants using an oscilloscope for two consecutive days. Interaction between plants was quantified by standard deviations (SDs) of the average voltage and frequency values. A higher standard deviation for these measures means that the plants interact better with each other for the corresponding position (i.e. , adjoining or social distance) and environment (i.e. , indoors or outdoors). The most fluctuating average voltage and frequency values were observed outdoors in the social distance position (SD = 5185.44mV) and outdoors in the adjoining position (SD = 3.01Hz). The smallest variations in average voltage values were obtained indoors at the social distance position (SD = 578.78mV). The average frequency values were in line with each other for the adjacent plants indoors (SD = 0.49Hz) , the social distance plants indoors (SD = 0.36Hz) and the social distance plants outdoors (SD = 0.40Hz). A mixed-modeling framework was used to investigate the effects of position , temperature , humidity and their interaction on the frequency and voltage values. These variables did not have a significant effect on the frequency and voltage values at the outdoor environment. Social distance had a positive effect on voltage values (/1 = 0.25, P = 0.033) indoors. Temperature had a negative impact on frequency values (/2 =-2.09, P = 0.040) and voltage values (/2 =-2.87, P = 0.005) indoors. Similarly , humidity negatively affected the frequency values (/3 =-1.26 , P = 0.033) and voltage values (/3 =-1.74, P = 0.003) indoors. The interaction effect between temperature and humidity was positive for both the frequency values (/4 = 0.04, P = 0.026) and voltage values (/4 = 0.06, P = 0.003) indoors.Öğe Nanoemulsion Hydrogel Delivery System of Hypericum perforatum L.: In Silico Design, In Vitro Antimicrobial-Toxicological Profiling, and In Vivo Wound-Healing Evaluation(Mdpi, 2025) Kurt, Ahmet Arif; Ibrahim, Bashar; Cinar, Harun; Atsu, Ayse Nilhan; Bursalioglu, Ertugrul Osman; Bayir, Ismail; Ozmen, OezlemHypericum perforatum L. (H.P.), a plant renowned for its wound-healing properties, was investigated for antioxidant/antimicrobial efficacy, toxicological safety, and in vivo wound-healing effects in this research to develop and characterize novel nanoemulsion hydrogel (NG) formulations. NG were prepared via emulsion diffusion-solvent evaporation and polymer hydration using Cremophor RH40 and Ultrez 21/30. A D-optimal design optimized oil/surfactant ratios, considering particle size, PDI, and drug loading. Antioxidant activity was tested via DPPH, ABTS+, and FRAP. Toxicological assessment followed HET-CAM (ICH-endorsed) and ICCVAM guidelines. The optimized NG-2 (NE-HPM-10 + U30 0.5%) demonstrated stable and pseudoplastic flow, with a particle size of 174.8 nm, PDI of 0.274, zeta potential of -23.3 mV, and 99.83% drug loading. Release followed the Korsmeyer-Peppas model. H.P. macerates/NEs showed potent antioxidant activity (DPPH IC50: 28.4 mu g/mL; FRAP: 1.8 mmol, Fe2+/g: 0.3703 +/- 0.041 mM TE/g). Antimicrobial effects against methicillin-resistant S. aureus (MIC: 12.5 mu g/mL) and E. coli (MIC: 25 mu g/mL) were significant. Stability studies showed no degradation. HET-CAM tests confirmed biocompatibility. Histopathology revealed accelerated re-epithelialization/collagen synthesis, with upregulated TGF-beta 1. The NG-2 formulation demonstrated robust antioxidant, antimicrobial, and wound-healing efficacy. Enhanced antibacterial activity and biocompatibility highlight its therapeutic potential. Clinical/pathological evaluations validated tissue regeneration without adverse effects, positioning H.P.-based nanoemulsions as promising for advanced wound care.Öğe The effects of fertilization on the green tea elements -2(Yildiz Technical University, 2019) Bursalioglu, Ertugrul OsmanCamellia sinensis, which is widely used as a beverage in our country and in the world, has various beneficial effects on human health due to its various components. Farmers use chemical fertilizers to get more products. However, the use of more chemical manure may cause some problems in terms of environmental pollution and human health. Due to the lack of some nutritious minerals in the soil, various manure ingredients are used for better cultivation and growth. In this study, in order to investigate the effect of use of manurate on tea plant on 5 different soils in Rize, the concentrations of 18 elements in the leaves were analyzed using the ICP-MS device. When manure was used in tea, the concentration of Li, Mg, K, Al, Ca, Cr, Mn, Fe, Cu, Zn, As, Se, Cd, Pb elements increased and Na, Co, Ni, Hg values decreased. © Yildiz Technical University, Environmental Engineering Department. All rights reserved.
