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    Öğe
    A polymeric copper complex based on a pyrazole derivative: Synthesis, spectroscopic, X-ray, and biological activity studies
    (Wiley, 2024) Amin, Mina A.; Diker, Halide; Sahin, Onur; Varlikli, Canan; Soliman, Ahmed A.
    A novel 1D coordination polymeric copper complex based on 4-(4 '-nitrophenylhydrazono)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was prepared and characterized spectroscopically and thermally and via X-ray crystallographic investigation. The prepared copper-based structure was proved to have a 1D coordination polymer. X-ray studies showed that the polymeric copper complex was of octahedral geometry, the ligand acted as a bidentate ligand, and the nitro group attached to the ligand acted as a bridging group. The cytotoxic activities of the copper polymer were evaluated including against MCF-7 cells (breast cancer cell line), HepG-2 cells (hepatocellular carcinoma), and HCT-116 cells (colon cancer cell line). The morphological alterations of the complex treated cells were investigated using an inverted microscope. The cell cycle and apoptosis were evaluated and reported. The copper polymer exhibited the best antitumor activity against HepG-2 cells (35.22 +/- 4.80 mu M) while also causing a decline in the G2/M phase and a remarkable enhancement in the early apoptosis. A novel polymeric Cu (II) complex based on 4-(4 '-nitrophenylhydrazono)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was prepared and characterized by spectroscopic, thermal, and X-ray crystallographic analysis techniques. The structure of the prepared complex was proved to have a polymeric nature with a copper center of octahedral geometry. The cytotoxic activities of the polymeric Cu (II) complex were evaluated including against mammalian cell lines: MCF-7 cells (human breast cancer cell line), HepG-2 cells (human hepatocellular carcinoma), and HCT-116 cells (human colon cancer cell line). image
  • [ X ]
    Öğe
    Copper and nickel complexes based on 4-((4-nitrophenyl) diazenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol; synthesis, characterization, X-ray studies, DFT calculations, molecular docking and antimicrobial activity
    (Elsevier, 2024) Amin, Mina A.; Diker, Halide; Sahin, Onur; Varlikli, Canan; Soliman, Ahmed A.
    Two new copper(II) and nickel(II) complexes were prepared using 4-((4-nitrophenyl)diazenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol (ndtp) and well-characterized spectroscopically and thermally and via X-ray studies. X-ray studies confirmed the formation of two octahedral complexes, containing two ndtp and two coordinated DMF molecules. The two complexes were evaluated in vitro against Escherichia coli, Pseudomonas aeruginosa, , Staphylococcus aureus and Bacillus cereus. . [Ni(ndtp)2(DMF)2] 2 (DMF) 2 ] showed an enhanced antibacterial activity against the different bacterial strains compared to the free ligand and that of the [Cu(ndtp)2(DMF)2]. 2 (DMF) 2 ]. The mean inhibition zones exhibited by [Ni(ndtp)2(DMF)2] 2 (DMF) 2 ] were 14.7+0.6, +0.6, 14.0+1.0, +1.0, and 16.3+0.6 +0.6 mm against Escherichia coli, , Staphylococcus aureus and Bacillus cereus, , respectively. Molecular docking studies of the two complexes were performed with DNA gyrase of Escherichia coli (PDB ID: 6F86) to evaluate the potential antibacterial activities, and it was proved that the complexes were efficient for the receptor.