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    Copper(II) monohelix complexes with pyrazine-modulated long-chain oligo-α-aminopyridine ligand: synthesis, crystal structures, and bioactivity studies
    (Elsevier, 2025) Ismayilova, Sabina Zahid; Ismayilov, Rayyat Huseyn; Tagiyev, Dilgam Babir; Senol, Halil; Medjidov, Ajdar Akber; Huseynova, Mansura Teyfur; Yalcin, Bahattin
    Using the pyrazine-modulated pentapyridyltetraamine ligand N-2,N-2 '-(pyridine-2,6-diyl)bis(N-6-(pyrazin-2-yl)pyridine-2,6-diamine) H4N9-2pz, three new mononuclear complexes [Cu(H4N9-2pz)](NO3)(2)center dot(CH3CN) 1, [Cu(H4N9-2pz)]Cl-2 center dot 2(H2O) 2 and [Cu(H3N9-2pz)] (CH3COO)center dot 2.5(H2O) 3 have been synthesized, structurally characterized, and their bioactivity properties studied. In vitro analysis of complexes 1-3 revealed that they inhibited AChE and BChE more effectively than the widely available inhibitor tacrine (IC50: 123.58 +/- 6.80 and 146.18 +/- 7.91 mu M). Additionally, their IC50 values for AChE and BChE ranged from 32.87 to 68.15 and 14.60 to 31.68 mu M, respectively. The g(
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    Cu(II) complex with thiosemicarbazone of glyoxylic acid as an anion ligand in a polymeric structure
    (Elsevier Science Bv, 2019) Huseynova, Mansura Teyfur; Aliyeva, Mahizar Nacaf; Medjidov, Ajdar Akber; Sahin, Onur; Yalcin, Bahattin
    A new complex of Cu(II), the composition Cu(C3H7N3O4S)center dot H2O, the reaction of thiosemicarbazone glyoxylic acid with copper nitrate in an aqueous medium was synthesised. X-ray diffraction analysis established the composition of the complexes was studied by IR, UV electronic absorption and EPR spectroscopy, and thermogravimetry. Thermogravimetry shows five stages of decomposition in the temperature range 90-990 degrees C. The magnetic susceptibility of the complex is studied. The value of mu(eff) for the complex is 1.76 BM, which is close to the value of one unpaired electron (1.73 BM). The ligand coordinates with the metal atom and consists of monoanionic Cu(C3H7N3O4S)center dot H2O polymeric complex connected by Cu-N bonds with neighbouring molecules. The metal centre coordinates with the oxygen of carboxylic, sulfur of thiolic and nitrogen of the azomethine group. The X-ray data and ESR spectra specify a distorted square pyramidal environment around Cu(II) ion. (C) 2018 Elsevier B.V. All rights reserved.
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    Novel zinc compound with thiosemicarbazone of glyoxylic acid: Synthesis, crystal structure, and bioactivity properties
    (Elsevier, 2020) Huseynova, Mansura; Farzaliyev, Vaqif; Medjidov, Ajdar; Aliyeva, Mahizar; Taslimi, Parham; Sahin, Onur; Yalcin, Bahattin
    Reaction of zinc nitrate with thiosemicarbazone of glyoxylic acid (H(2)GAT) leads to the formation of the new complex that have been characterized by spectroscopic methods. Crystal structure of the compound Zn3C18H34N18O17S6 (1) was determined using single crystal X-ray diffraction methods. Single crystal X-ray measurements showed that the complex crystallized in a triclinic system with the space group P-1. The structure of complex 1 presents distorted octahedral geometry around the zinc ion centre. In the crystal structure, Zn(II) ion is coordinated by two nitrogen, two oxygen and two sulfur atoms from two different thiosemicarbazone of glyoxylic acid and two oxygen atoms from two different water molecules. Thermogravimetry shows four steps of decomposition in the temperature range 225-990 degrees C. This complex was an inhibitor of butyrylcholinesterase (BChE), cytosolic carbonic anhydride I and II isoforms (hCA I and II) and acetylcholinesterase (AChE) enzymes for complex 1 with Ki values of 0.95 +/- 0.10 mu M for hCA I, 1.54 +/- 0.24 mu M for hCA II, 25.98 +/- 2.44 mu M for BChE, 166.21 +/- 13.63 mu M for alpha-glycosidase and 18.53 +/- 1.36 mu M for AChE, respectively. (C) 2019 Elsevier B.V. All rights reserved.
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    Synthesis and characterization of Cu(II) complexes of pyrazine-2,3-dicarboxylicacid
    (Pergamon-Elsevier Science Ltd, 2011) Tascioglu, Sulin; Aydin, Adnan; Yalcin, Bahattin; Kaki, Esra; Andac, Omer; Buyukgungor, Orhan; Kosar, Basak
    Four copper(II) coordination polymers, {[Cu(pz(COO)(2))(H2O)](4)center dot HBr}(n) (1). {[Cu(pz(COO)(2))(NH3)(2)]center dot H2O}(n) (2), {[Cu3H2(pz(COO)(2))(4)(H2O)(3)]center dot 2H(2)O}(n) (3) and {[Cu-2(pz(COO)(2))(2)(NH3)(2)(H2O)(3)][Cu(pz(COO)(2))(NH3) (H2O)(2)][Cu(pz(COO)(2))(NH3)(H2O)]center dot 2H(2)O}(n) (4) were synthesized using pyrazine-2,3-dicarboxylic acid, CuBr2, 2-(2-aminoethylamino)ethanol/triethanol amine/ammonia in a methanol:water (1:1) solution, and the mixed ligand complexes were characterized by spectroscopic methods, thermal and elemental analysis, and magnetic susceptibility. Complexes 2 and 4 were also characterized by means of single crystal X-ray crystallography. The characterizations show that the complexes have polynuclear molecular structures, except for complex 2, and all of the complex structures form polymeric chains. Complex 4 has a pseudo-merohedral twin structure. (C) 2011 Elsevier Ltd. All rights reserved.
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    Synthesis, structure, and properties of a polymeric copper(II) complex with anion of maleic acid
    (Springer, 2025) Guliyeva, Esmira Arif Aga; Mejidov, Ajdar Akper; Ismayilov, Rayyat Huseyn; Rustam, Malahat Bagiyeva; Yalcin, Bahattin; Ozturkkan, Fureya Elif; Sahin, Onur
    A new polymeric copper(II)-maleato complex, used as a dicarboxylate ligand, was synthesized {Na2[Cu(C4H2O4)2]2H2O}n (1). The resulting complex was characterized by elemental analysis, infrared and UV-visible spectroscopy, and X-ray crystallography. Spectroscopic data indicate that the maleato ion coordinates in a chelating bidentate mode, creating a distorted square planar coordination environment around Cu(II). X-ray crystallography confirmed the formulation (1) and revealed that the central Cu(II) ion is in a distorted square planar. The maleato ion acts as a bidentate chelator, coordinating through two carboxylate oxygens to form a stable four-membered ring. This study extends our understanding of the coordination behavior of pi-conjugated dicarboxylic acids with transition-metal ions. Molecular docking studies demonstrated that the polymeric copper(II)-maleic acid complex exhibited strong binding affinity toward B-DNA (1BNA), with a binding energy of - 10.2 kcal/mol and multiple stable hydrogen bond interactions. The molecular docking results demonstrated that the polymeric copper(II) complex with maleic acid forms conventional hydrogen bonds with B-DNA. Specifically, interactions were observed with guanine and cytosine bases: the O2 atom of cytosine (DC21), the O4 ' atom of guanine (DG24), and the hydrogen atoms of guanine residues DG2, DG4, and DG22. The hydrogen bond distances (2.10-2.89 & Aring;) confirm the stability of these interactions. Moreover, several of these interactions are located within or near the minor groove of DNA, indicating a groove-binding mode. In addition, the complex exhibits an intramolecular hydrogen bond that stabilizes its conformation during binding.